通过非对映选择性氢化锆反应来获得对映体富集的顺式-2,3-二取代氮杂环丁烷。
Access to enantiomerically enriched cis-2,3-disubstituted azetidines via diastereoselective hydrozirconation.
机构信息
Institut de Chimie Moléculaire de Reims, CNRS (UMR 6229) and Université de Reims, 51687 Reims Cedex 2, France.
出版信息
Org Lett. 2011 Apr 1;13(7):1793-5. doi: 10.1021/ol200323r. Epub 2011 Mar 8.
PMID:21384824
Abstract
An asymmetric variant of the hydrozirconation reaction has been established starting from Boc-protected chiral allylic amines. The resulting diastereoselectively formed N-functionalized organozirconiums can be considered as promising chirons. In this case, they have been transformed into enantiomerically enriched cis-2,3-disubstituted azetidines through a iodination/cyclization sequence.
摘要
已建立了一种从 Boc 保护的手性烯丙基胺开始的不对称水合锆反应变体。所得非对映选择性形成的 N-官能化有机锆可以被认为是有前途的手性中心。在这种情况下，它们通过碘化/环化序列转化为对映体富集的顺式-2,3-二取代氮杂环丁烷。
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