Département de Chimie and PROTEO, Faculté des Sciences et de Génie, Université Laval, Pavillon Alexandre-Vachon, 1045 avenue de la Médecine, Québec, QC, Canada, G1V 0A6.
J Am Chem Soc. 2011 May 4;133(17):6481-3. doi: 10.1021/ja110336s. Epub 2011 Mar 8.
Analogues of a synthetic ion channel made from a helical peptide were used to study the mechanism of cation translocation within bilayer membranes. Derivatives bearing two, three, four, and six crown ethers used as ion relays were synthesized, and their transport abilities across lipid bilayers were measured. The results showed that the maximum distance a sodium ion is permitted to travel between two binding sites within a lipid bilayer environment is 11 Å.
合成离子通道的类似物由螺旋肽制成,用于研究阳离子在双层膜内的迁移机制。合成了带有两个、三个、四个和六个冠醚作为离子继电器的衍生物,并测量了它们在脂质双层中的传输能力。结果表明,钠离子在脂质双层环境中两个结合位点之间允许移动的最大距离为 11Å。