Atherton D J, Sutton C, Jones B M
Department of Dermatology, Hospital for Sick Children, London, U.K.
Br J Dermatol. 1990 Feb;122(2):245-52. doi: 10.1111/j.1365-2133.1990.tb08271.x.
We report the case of a boy, now aged 4 years, with a progressive, painful and disabling palmoplantar keratoderma, associated with well-defined hyperkeratotic plaques around the mouth and nostrils. His mother has an identical palmoplantar keratoderma. The palmoplantar keratoderma failed to improve with etretinate, but considerable benefit resulted from full-thickness excision of the skin of both palms, followed by skin grafting. We believe that he has a distinctive but extremely rare form of hereditary palmoplantar keratoderma, first described by Olmsted.
我们报告了一名4岁男孩的病例，他患有进行性、疼痛性且致残性掌跖角化病，伴有口周和鼻孔周围边界清晰的角化过度斑块。他的母亲患有相同的掌跖角化病。维甲酸治疗未能改善其掌跖角化病，但双手掌皮肤全层切除并植皮后有显著疗效。我们认为他患有一种独特但极为罕见的遗传性掌跖角化病，最初由奥姆斯特德描述。
