Ueda M, Nakagawa K, Hayashi K, Shimizu R, Ichihashi M
Department of Dermatology, School of Medicine, Kobe University, Japan.
Pediatr Dermatol. 1993 Dec;10(4):376-81. doi: 10.1111/j.1525-1470.1993.tb00404.x.
An 11-year-old Japanese boy with Olmsted syndrome was seen at our clinic. He had a sharply marginated, painful keratoderma with a red border on his palms and soles. Flexion contractures of the fingers were also observed. Hyperkeratotic plaques were present below the lower lip, on the elbows and knees, and in the sacral area. Localized alopecia, leukokeratosis on the tongue, shortness of stature, and laxity of the large joints corresponded to the clinical features of Olmsted syndrome. Treatment with etretinate was effective for the palms and fingers, but resulted in no improvement of the keratoderma of the soles. Because of periosteal thickening of the tibia, presumably caused by etretinate, therapy was terminated one year after it began.
一名患有奥姆斯特德综合征的11岁日本男孩前来我们诊所就诊。他的手掌和脚底有边界清晰、疼痛的角化皮肤病，边缘呈红色。还观察到手指屈曲挛缩。下唇下方、肘部、膝盖和骶骨区域有角化过度斑块。局部脱发、舌部白色角化病、身材矮小和大关节松弛符合奥姆斯特德综合征的临床特征。用依曲替酯治疗对手掌和手指有效，但对脚底的角化皮肤病没有改善。由于依曲替酯可能导致胫骨骨膜增厚，治疗开始一年后终止。
