Margaritopoulos Giorgos A, Antoniou Katerina M, Soufla Giannoula, Vassalou Evi, Spandidos Demetrios A, Siafakas Nikos M
Interstitial Lung Disease Unit, Department of Thoracic Medicine, University Hospital of Heraklion, Crete, Greece.
J Recept Signal Transduct Res. 2011 Apr;31(2):188-91. doi: 10.3109/10799893.2011.557735.
Yin Yang-1 (YY-1) is implicated in the pathogenesis of lung cancer which can be complicated with idiopathic pulmonary fibrosis (IPF).
The aim of the study was to investigate whether YY-1 is involved in the pathogenesis of IPF and whether represents a common pathogenetic pathway which could explain the coexistence of these disorders.
Lung tissue from 52 patients (37 with IPF and 15 controls) and bronchoalveolar lavage fluid (BALF) from 34 patients (25 with IPF and 9 controls) were studied and YY-1 mRNA expression was evaluated by real-time PCR.
YY-1 was expressed in 8% (3/37) of IPF patients and in 6% (1/15) of healthy controls in tissue samples. In addition, 12% (3/25) of IPF patients and 33% (3/9) of healthy controls have expressed YY-1 gene in BALF samples. However, no statistical significant difference in mRNA expression between patients and controls has been detected in both tissue and BAL fluid samples.
Our results do not support the hypothesis of YY-1 involvement in IPF. However, similar expression of YY-1 gene in two biological samples cannot exclude a possible role of this polymorphic gene in the pathway of IPF. Further studies in a larger scale of patients are needed.
阴阳-1（YY-1）与肺癌发病机制有关，而肺癌可能并发特发性肺纤维化（IPF）。
本研究旨在探讨YY-1是否参与IPF的发病机制，以及是否代表一种可解释这些疾病共存的共同发病途径。
研究了52例患者（37例IPF患者和15例对照）的肺组织以及34例患者（25例IPF患者和9例对照）的支气管肺泡灌洗液（BALF），并通过实时PCR评估YY-1 mRNA表达。
在组织样本中，8%（3/37）的IPF患者和6%（1/15）的健康对照表达YY-1。此外，在BALF样本中，12%（3/25）的IPF患者和33%（3/9）的健康对照表达YY-1基因。然而，在组织和BALF样本中，患者与对照之间的mRNA表达均未检测到统计学显著差异。
我们的结果不支持YY-1参与IPF的假说。然而，YY-1基因在两个生物样本中的相似表达不能排除该多态性基因在IPF发病途径中的可能作用。需要对更大规模的患者进行进一步研究。
