Department of Haematology, VU University Medical Center, De Boelelaan 1117, Amsterdam, the Netherlands.
Br J Haematol. 2011 May;153(4):421-36. doi: 10.1111/j.1365-2141.2011.08595.x. Epub 2011 Mar 9.
This article reviews the use of aberrant antigen expression detected by flow cytometry in the diagnosis and clinical handling of acute myeloid leukaemia (AML) and the myelodysplastic syndromes (MDS). Such aberrancies offer a valuable tool for the proper classification of these myeloid malignancies according the World Health Organization 2008 classification. Aberrant antigen expression by flow cytometry is also important for prognostification. This review supports the view, that minimal residual disease detection methods that make use of such aberrancies should be part of the routine management of AML patients to guide therapy, but also suggests the introduction of flow cytometry in MDS for diagnosis and treatment decisions in the near future.
本文综述了流式细胞术检测异常抗原表达在急性髓系白血病（AML）和骨髓增生异常综合征（MDS）诊断和临床处理中的应用。这些异常为根据世界卫生组织 2008 年分类法对这些髓系恶性肿瘤进行正确分类提供了有价值的工具。流式细胞术检测的异常抗原表达对预后也很重要。这篇综述支持这样的观点，即利用这些异常的微小残留病检测方法应该成为 AML 患者常规管理的一部分，以指导治疗，但也建议在 MDS 中引入流式细胞术，以便在不久的将来做出诊断和治疗决策。
