成年早期的精神障碍与 1946 年英国出生队列人群的过早死亡风险。
Psychiatric disorder in early adulthood and risk of premature mortality in the 1946 British Birth Cohort.
机构信息
King's College London, Institute of Psychiatry, Department of Psychological Medicine, Weston Education Centre, Cutcombe Road, London SE5 9RJ UK.
出版信息
BMC Psychiatry. 2011 Mar 8;11:37. doi: 10.1186/1471-244X-11-37.
BACKGROUND
Few studies of the association between psychiatric disorder and premature death have adjusted for key confounders and used structured psychiatric interviews. We aimed to investigate if psychiatric disorder was associated with a higher risk of mortality and whether any excess mortality was due to suicide, or explained by other health or socioeconomic risk factors.
METHODS
We used data from the MRC National Survey of Health and Development, a nationally representative UK birth cohort. 3283 men and women completed the Present State Examination at age 36. The main outcome measure was all-cause mortality before age 60.
RESULTS
Those with psychiatric disorder at age 36 had a higher risk of death even after adjusting for potential confounders (Hazard ratio = 1.84, 95% C.I. 1.22-2.78). Censoring violent deaths and suicides led to similar results.
CONCLUSIONS
Psychiatric disorder was associated with excess premature mortality not explained by suicide or other health or socioeconomic risk factors.
背景
很少有研究对精神障碍与过早死亡之间的关系进行调整，以考虑关键混杂因素并使用结构化的精神科访谈。我们旨在调查精神障碍是否与更高的死亡风险相关，以及任何超额死亡是否归因于自杀，或者是否可以通过其他健康或社会经济风险因素来解释。
方法
我们使用了 MRC 国家健康发展调查的数据，这是一项具有全国代表性的英国出生队列研究。3283 名男性和女性在 36 岁时完成了现状检查。主要结局指标是 60 岁前的全因死亡率。
结果
即使在调整了潜在混杂因素后（危险比=1.84，95%置信区间 1.22-2.78），在 36 岁时患有精神障碍的人死亡风险也更高。对暴力死亡和自杀进行删失后得到了类似的结果。
结论
精神障碍与超额的早逝相关，无法用自杀或其他健康或社会经济风险因素来解释。
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