Depto. de Genética Molecular, Inst. de Fisiología Celular, Universidad Nacional Autónoma de México, México City, Mexico.
Mitochondrion. 2011 May;11(3):382-90. doi: 10.1016/j.mito.2011.02.004. Epub 2011 Mar 6.
Mitochondria from diverse species can undergo a massive permeability increase known as the permeability transition, a process first thought to be an artifact. It is currently accepted that in the inner mitochondrial membrane there is a Mitochondrial Unselective Channel (MUC), also known as the permeability transition pore. Regardless of the species, MUC opening leads to uncoupling of oxidative phosphorylation. In each species, MUC regulation appears to be different, probably as a result of the adaptation of each organism to its specific environment. To date, the components and the putative physiological role of MUCs are still a matter of debate. Current hypothesis suggests that proteins normally participating in diverse metabolic functions constitute MUCs. Among these proteins, the Adenine Nucleotide Translocase and the phosphate carrier have been proposed as putative MUC components in mammalian and yeast mitochondria. In this review, the characteristics of MUCs from different species and strains are discussed. The data from the literature reinforce the current notion that these channels are preserved through evolution albeit with different control factors. We emphasize the knowledge available of Mitochondrial Unselective Channels from different yeast species.
来自不同物种的线粒体可以经历一种称为通透性转变的大规模通透性增加，这一过程最初被认为是一种假象。目前人们普遍认为，在内膜线粒体中有一个线粒体非选择性通道（MUC），也称为通透性转变孔。无论物种如何，MUC 的开放都会导致氧化磷酸化的解偶联。在每个物种中，MUC 的调节似乎都不同，这可能是由于每个生物体对其特定环境的适应。迄今为止，MUC 的组成和假定的生理作用仍然存在争议。目前的假设表明，通常参与多种代谢功能的蛋白质构成了 MUC。在这些蛋白质中，腺嘌呤核苷酸转位酶和磷酸载体已被提议为哺乳动物和酵母线粒体中 MUC 的可能组成部分。在这篇综述中，讨论了不同物种和菌株的 MUC 的特征。文献中的数据进一步证实了目前的观点，即这些通道在进化过程中是被保留下来的，尽管它们有不同的控制因素。我们强调了不同酵母物种的线粒体非选择性通道的现有知识。
