Department of Pediatric Critical Care Medicine, Changhua Christian Hospital, Changhua, Taiwan.
Pediatr Neonatol. 2011 Feb;52(1):24-9. doi: 10.1016/j.pedneo.2010.12.008. Epub 2011 Feb 24.
The PalmLab glucometer is a newly designed plasma separation glucose oxidase (GO)-based glucometer. Past studies have shown that the accuracy of GO-based glucometers is compromised when measurements are taken in patients with high PO(2) levels. We performed a two-arm study comparing the fitness of the PalmLab blood glucometer with that of a standard glucose analyzer in monitoring blood glucose levels in pediatric patients, especially when arterial partial pressure of oxygen (PO(2)) was high.
In the first arm of the study, arterial blood samples from pediatric patients were measured by the PalmLab blood glucometer and the YSI 2302 Plus Glucose/Lactate analyzer. In the second arm of the study, venous blood samples from adult volunteers were spiked with glucose water to prepare three different levels of glucose (65, 150, and 300mg/dL) and then oxygenated to six levels of PO(2) (range, 40-400mmHg). The biases of the PalmLab glucometer were calculated.
A total of 162 samples were collected in the first arm of the study. Results of linear regression showed that the coefficient of determination (R(2)) between PalmLab glucometer and standard glucose analyzer was 0.9864. Error grid analysis revealed that all the results were within Zone A (clinically accurate estimate zone). The biases between the two systems were low at different PO(2) levels. In the second arm of the study, the results were also unaffected by changes in PO(2).
The PalmLab glucometer provides accurate results in samples with high PO(2) and is suitable for measuring arterial glucose levels in pediatric patients.
PalmLab 血糖仪是一种新设计的血浆分离葡萄糖氧化酶（GO）血糖仪。过去的研究表明，当在高 PO₂水平的患者中进行测量时，基于 GO 的血糖仪的准确性会受到影响。我们进行了一项双臂研究，比较了 PalmLab 血糖仪与标准葡萄糖分析仪在监测儿科患者血糖水平方面的适用性，尤其是在动脉血氧分压（PO₂）较高时。
在研究的第一臂中，使用 PalmLab 血糖仪和 YSI 2302 Plus 葡萄糖/乳酸分析仪测量儿科患者的动脉血样。在研究的第二臂中，从成年志愿者抽取静脉血样，用葡萄糖水进行加标，制备三个不同葡萄糖水平（65、150 和 300mg/dL），然后氧合至六个不同的 PO₂水平（范围 40-400mmHg）。计算 PalmLab 血糖仪的偏差。
在研究的第一臂中总共收集了 162 个样本。线性回归结果表明，PalmLab 血糖仪和标准葡萄糖分析仪之间的决定系数（R²）为 0.9864。误差网格分析显示，所有结果均位于 Zone A（临床准确估计区）内。在不同的 PO₂水平下，两种系统之间的偏差较低。在研究的第二臂中，PO₂变化也不会影响结果。
PalmLab 血糖仪在高 PO₂样本中提供准确的结果，适用于测量儿科患者的动脉血糖水平。
