Department of Neonatology, Changhua Christian Hospital, , Changhua, Taiwan.
Arch Dis Child Fetal Neonatal Ed. 2013 Nov;98(6):F545-8. doi: 10.1136/archdischild-2012-303613. Epub 2013 Jul 9.
The purpose of this study was to evaluate the accuracy of a novel commercial glucose-oxidase (GO)-based glucometer in measuring glucose concentrations in arterial blood samples collected from premature infants.
A commercial glucometer, which is a plasma separation GO-based glucometer, was employed to compare the accuracy of the commercial blood glucometer with that of a standard glucose analyser for monitoring blood glucose levels in premature infants. Arterial blood samples were collected and analysed, including samples adjusted for specific glucose (3.6 mmol/L, 8.3 mmol/L and 16.7 mmol/L) and PaO2 levels (range, 40-400 mm Hg).
In total, 159 samples were collected. Bland-Altman analysis showed good correlation between the commercial glucometer and standard glucose analyser. Error-grid analysis revealed that all of the results were within zone A (ie, the clinically accurate estimate zone). The biases between the two systems were low at different PaO2 levels and haematocrits. Finally, the influence of different PaO2 levels was within acceptable ranges.
The GO-based glucometer evaluated in this study provides accurate results even when measured at high PaO2 and different haematocrits and is suitable for measuring arterial glucose levels in premature infants.
本研究旨在评估一种新型商业葡萄糖氧化酶（GO）血糖仪测量早产儿动脉血样中葡萄糖浓度的准确性。
采用一种商业血糖仪，即基于血浆分离的 GO 血糖仪，与标准血糖仪对比，监测早产儿的血糖水平。采集并分析动脉血样，包括针对特定葡萄糖（3.6mmol/L、8.3mmol/L 和 16.7mmol/L）和 PaO2 水平（范围：40-400mmHg）进行调整的样本。
共采集了 159 个样本。Bland-Altman 分析显示，商业血糖仪与标准葡萄糖分析仪之间具有良好的相关性。误差网格分析显示，所有结果均位于 A 区（即临床准确估计区）。在不同的 PaO2 水平和血细胞比容下，两个系统之间的偏差较低。最后，不同 PaO2 水平的影响在可接受的范围内。
本研究评估的基于 GO 的血糖仪即使在高 PaO2 和不同血细胞比容下测量，也能提供准确的结果，适用于测量早产儿的动脉血糖水平。
