Department of Neurobiology, University of Chicago, Chicago, IL 60637, USA.
Cereb Cortex. 2011 Nov;21(11):2425-41. doi: 10.1093/cercor/bhr029. Epub 2011 Mar 8.
Little is known regarding the synaptic properties of corticocortical connections from one cortical area to another. To expand on this knowledge, we assessed the synaptic properties of excitatory projections from the primary to secondary auditory cortex and vice versa. We identified 2 types of postsynaptic responses. The first class of responses have larger initial excitatory postsynaptic potentials (EPSPs), exhibit paired-pulse depression, are limited to ionotropic glutamate receptor activation, and have larger synaptic terminals; the second has smaller initial EPSPs, paired-pulse facilitation, metabotropic glutamate receptor activation, and smaller synaptic terminals. These responses are similar to the driver and modulator properties previously identified for thalamic and thalamocortical circuitry, suggesting that the same classification may extend to corticocortical inputs and have an implication for the functional organization of corticocortical circuits.
对于来自一个皮质区域到另一个皮质区域的皮质皮质连接的突触特性知之甚少。为了扩展这方面的知识，我们评估了来自初级听觉皮层到次级听觉皮层的兴奋性投射的突触特性，反之亦然。我们确定了 2 种类型的突触后反应。第一类反应具有更大的初始兴奋性突触后电位（EPSP），表现出成对脉冲抑制，仅限于离子型谷氨酸受体激活，并且具有更大的突触末端；第二类具有较小的初始 EPSP、成对脉冲易化、代谢型谷氨酸受体激活和较小的突触末端。这些反应类似于先前为丘脑和丘脑皮质回路确定的驱动和调制特性，表明相同的分类可能扩展到皮质皮质输入，并对皮质皮质回路的功能组织具有影响。
