Department of Neurobiology, University of Chicago, Chicago, Illinois 60637, USA.
J Neurosci. 2011 Nov 16;31(46):16494-506. doi: 10.1523/JNEUROSCI.3664-11.2011.
Despite the importance of corticocortical connections, few published studies have investigated the functional, synaptic properties of such connections in any species, because most studies have been purely anatomical or aimed at functional features other than synaptic properties. We recently published a study of synaptic properties of connections between the primary and secondary cortical auditory areas in brain slices from the mouse, and, in the present study, we aimed to extend this by performing analogous studies of the primary and secondary visual areas (V1 and V2). We found effectively the same results. That is, connections between V1 and V2 in both directions were quite similar; in each case, the glutamatergic inputs could be classified as one of two types, Class 1B (formerly "driver") and Class 2 (formerly "modulator"). There is a clear laminar correlation for these different inputs, in terms of both the laminae of origin and those in which the recorded cells were located. Our data suggest a common pattern to the functional organization of corticocortical connectivity in the mouse cortex.
尽管皮质间连接非常重要，但由于大多数研究纯粹是解剖学的，或者针对的是除突触特性以外的功能特征，因此很少有发表的研究调查过任何物种中此类连接的功能、突触特性。我们最近发表了一项关于从老鼠大脑切片中初级和次级皮质听觉区域之间连接的突触特性的研究，在本研究中，我们旨在通过对初级和次级视觉区域（V1 和 V2）进行类似的研究来扩展这一研究。我们得到了几乎相同的结果。也就是说，V1 和 V2 之间的双向连接非常相似；在每种情况下，谷氨酸能输入都可以分为两种类型之一，即 1B 类（以前称为“驱动”）和 2 类（以前称为“调制”）。这些不同的输入在起源层和记录细胞所在的层之间都有明显的分层相关性。我们的数据表明，在小鼠皮层中，皮质间连接的功能组织具有共同的模式。
