• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Normalizing a hyperactive mTOR initiates muscle growth during obesity.

作者信息

Williamson David L

机构信息

Department of Exercise and Nutrition Sciences, School of Public Health, University at Buffalo, Buffalo, NY 14214, USA.

出版信息

Aging (Albany NY). 2011 Feb;3(2):83-4. doi: 10.18632/aging.100290.

DOI:10.18632/aging.100290
PMID:21386136
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3082017/
Abstract
摘要

相似文献

1
Normalizing a hyperactive mTOR initiates muscle growth during obesity.使过度活跃的雷帕霉素靶蛋白（mTOR）正常化可在肥胖期间启动肌肉生长。
Aging (Albany NY). 2011 Feb;3(2):83-4. doi: 10.18632/aging.100290.
2
Caloric Restriction Normalizes Obesity-Induced Alterations on Regulators of Skeletal Muscle Growth Signaling.热量限制可使肥胖引起的骨骼肌生长信号调节因子的改变恢复正常。
Lipids. 2016 Aug;51(8):905-12. doi: 10.1007/s11745-016-4168-3. Epub 2016 Jun 11.
3
Chronic high fat feeding attenuates load-induced hypertrophy in mice.慢性高脂肪喂养可减弱小鼠因负荷引起的肥大。
J Physiol. 2009 Dec 1;587(Pt 23):5753-65. doi: 10.1113/jphysiol.2009.180174. Epub 2009 Oct 12.
4
mTOR signaling as a target of amino acid treatment of the age-related sarcopenia.mTOR信号传导作为与年龄相关的肌肉减少症氨基酸治疗的靶点。
Interdiscip Top Gerontol. 2010;37:115-41. doi: 10.1159/000319998. Epub 2010 Aug 10.
5
Mammalian target of rapamycin (mTOR) signaling network in skeletal myogenesis.哺乳动物雷帕霉素靶蛋白（mTOR）信号网络在骨骼肌生成中的作用。
J Biol Chem. 2012 Dec 21;287(52):43928-35. doi: 10.1074/jbc.R112.406942. Epub 2012 Oct 31.
6
The mechanistic and ergogenic effects of phosphatidic acid in skeletal muscle.磷脂酸在骨骼肌中的作用机制及促力效应。
Appl Physiol Nutr Metab. 2015 Dec;40(12):1233-41. doi: 10.1139/apnm-2015-0350. Epub 2015 Sep 21.
7
Muscle-to-fat interaction: a two-way street?肌肉与脂肪的相互作用：是双向的吗？
J Physiol. 2010 Jan 1;588(Pt 1):21. doi: 10.1113/jphysiol.2009.184747.
8
S6K1 Is Required for Increasing Skeletal Muscle Force during Hypertrophy.S6K1是肌肉肥大过程中增加骨骼肌力量所必需的。
Cell Rep. 2016 Oct 4;17(2):501-513. doi: 10.1016/j.celrep.2016.09.020.
9
Sarcopenia: Tilting the Balance of Protein Homeostasis.肌肉减少症：平衡蛋白质动态平衡的倾斜。
Proteomics. 2020 Mar;20(5-6):e1800411. doi: 10.1002/pmic.201800411. Epub 2019 Dec 4.
10
AMPKγ3 is dispensable for skeletal muscle hypertrophy induced by functional overload.AMPKγ3对于功能性超负荷诱导的骨骼肌肥大并非必需。
Am J Physiol Endocrinol Metab. 2016 Mar 15;310(6):E461-72. doi: 10.1152/ajpendo.00387.2015. Epub 2016 Jan 12.

引用本文的文献

1
Iron Transporters and Ferroptosis in Malignant Brain Tumors.恶性脑肿瘤中的铁转运蛋白与铁死亡
Front Oncol. 2022 Apr 21;12:861834. doi: 10.3389/fonc.2022.861834. eCollection 2022.
2
Effects of Resistance Exercise and Fermented Soybean Consumption on Glucose Tolerance and Expressions of Immune Senescence-Related Myokines in Middle-Aged Obese Rats.抗阻运动和食用发酵大豆对中年肥胖大鼠葡萄糖耐量及免疫衰老相关肌动蛋白表达的影响
J Obes Metab Syndr. 2018 Sep 30;27(3):186-194. doi: 10.7570/jomes.2018.27.3.186.
3
Effects of treadmill exercise on skeletal muscle mTOR signaling pathway in high-fat diet-induced obese mice.跑步机运动对高脂饮食诱导的肥胖小鼠骨骼肌mTOR信号通路的影响
J Phys Ther Sci. 2016 Apr;28(4):1260-5. doi: 10.1589/jpts.28.1260. Epub 2016 Apr 28.
4
Alpha-lipoic acid supplementation reduces mTORC1 signaling in skeletal muscle from high fat fed, obese Zucker rats.补充α-硫辛酸可降低高脂喂养的肥胖 Zucker 大鼠骨骼肌中的 mTORC1 信号传导。
Lipids. 2014 Dec;49(12):1193-201. doi: 10.1007/s11745-014-3964-x. Epub 2014 Nov 1.
5
Dysregulation of SIRT-1 in aging mice increases skeletal muscle fatigue by a PARP-1-dependent mechanism.衰老小鼠中SIRT-1的失调通过一种PARP-1依赖性机制增加骨骼肌疲劳。
Aging (Albany NY). 2014 Oct;6(10):820-34. doi: 10.18632/aging.100696.
6
Ketogenic diet in neuromuscular and neurodegenerative diseases.生酮饮食在神经肌肉疾病和神经退行性疾病中的应用
Biomed Res Int. 2014;2014:474296. doi: 10.1155/2014/474296. Epub 2014 Jul 3.
7
TOR-centric view on insulin resistance and diabetic complications: perspective for endocrinologists and gerontologists.从 TOR 角度探讨胰岛素抵抗与糖尿病并发症：内分泌学家和老年病学家的观点。
Cell Death Dis. 2013 Dec 12;4(12):e964. doi: 10.1038/cddis.2013.506.
8
CDK4/6-inhibiting drug substitutes for p21 and p16 in senescence: duration of cell cycle arrest and MTOR activity determine geroconversion.CDK4/6 抑制剂在衰老中替代 p21 和 p16：细胞周期阻滞的持续时间和 MTOR 活性决定了衰老的转化。
Cell Cycle. 2013 Sep 15;12(18):3063-9. doi: 10.4161/cc.26130. Epub 2013 Aug 22.
9
Sarcopenia, a neurogenic syndrome?少肌症，一种神经源性综合征？
J Aging Res. 2013;2013:791679. doi: 10.1155/2013/791679. Epub 2013 Mar 13.
10
Advances in targeting signal transduction pathways.靶向信号转导通路的进展。
Oncotarget. 2012 Dec;3(12):1505-21. doi: 10.18632/oncotarget.802.

本文引用的文献

1
mTORC1 controls fasting-induced ketogenesis and its modulation by ageing.mTORC1 调控饥饿诱导的酮体生成及其被衰老调控。
Nature. 2010 Dec 23;468(7327):1100-4. doi: 10.1038/nature09584.
2
AICAR treatment for 14 days normalizes obesity-induced dysregulation of TORC1 signaling and translational capacity in fasted skeletal muscle.用 AICAR 治疗 14 天可使肥胖引起的禁食骨骼肌中 TORC1 信号和翻译能力的失调恢复正常。
Am J Physiol Regul Integr Comp Physiol. 2010 Dec;299(6):R1546-54. doi: 10.1152/ajpregu.00337.2010. Epub 2010 Sep 15.
3
Downregulation of AMPK accompanies leucine- and glucose-induced increases in protein synthesis and insulin resistance in rat skeletal muscle.AMPK 的下调伴随着亮氨酸和葡萄糖诱导的大鼠骨骼肌蛋白质合成和胰岛素抵抗的增加。
Diabetes. 2010 Oct;59(10):2426-34. doi: 10.2337/db09-1870. Epub 2010 Aug 3.
4
Rapamycin and quasi-programmed aging: four years later.雷帕霉素与准程序老化：四年之后。
Cell Cycle. 2010 May 15;9(10):1859-62. doi: 10.4161/cc.9.10.11872.
5
Rapamycin extends maximal lifespan in cancer-prone mice.雷帕霉素延长易患癌症的小鼠的最大寿命。
Am J Pathol. 2010 May;176(5):2092-7. doi: 10.2353/ajpath.2010.091050. Epub 2010 Apr 2.
6
Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.核糖体蛋白S6激酶1信号通路调节哺乳动物寿命。
Science. 2009 Oct 2;326(5949):140-4. doi: 10.1126/science.1177221.
7
Aerobic exercise training improves whole muscle and single myofiber size and function in older women.有氧运动训练可改善老年女性的全肌和单根肌纤维大小及功能。
Am J Physiol Regul Integr Comp Physiol. 2009 Nov;297(5):R1452-9. doi: 10.1152/ajpregu.00354.2009. Epub 2009 Aug 19.
8
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice.在生命后期喂食雷帕霉素可延长基因异质小鼠的寿命。
Nature. 2009 Jul 16;460(7253):392-5. doi: 10.1038/nature08221. Epub 2009 Jul 8.
9
Morphological and biochemical alterations of skeletal muscles from the genetically obese (ob/ob) mouse.遗传性肥胖（ob/ob）小鼠骨骼肌的形态和生化改变。
Int J Obes (Lond). 2009 Aug;33(8):831-41. doi: 10.1038/ijo.2009.100. Epub 2009 Jun 16.
10
Sarcopenic obesity: definition, cause and consequences.肌少性肥胖：定义、成因及后果
Curr Opin Clin Nutr Metab Care. 2008 Nov;11(6):693-700. doi: 10.1097/MCO.0b013e328312c37d.