Normalizing a hyperactive mTOR initiates muscle growth during obesity.
作者信息
Williamson David L
机构信息
Department of Exercise and Nutrition Sciences, School of Public Health, University at Buffalo, Buffalo, NY 14214, USA.
出版信息
Aging (Albany NY). 2011 Feb;3(2):83-4. doi: 10.18632/aging.100290.
Abstract
摘要
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本文引用的文献
1
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Nature. 2010 Dec 23;468(7327):1100-4. doi: 10.1038/nature09584.
2
AICAR treatment for 14 days normalizes obesity-induced dysregulation of TORC1 signaling and translational capacity in fasted skeletal muscle.用 AICAR 治疗 14 天可使肥胖引起的禁食骨骼肌中 TORC1 信号和翻译能力的失调恢复正常。
Am J Physiol Regul Integr Comp Physiol. 2010 Dec;299(6):R1546-54. doi: 10.1152/ajpregu.00337.2010. Epub 2010 Sep 15.
3
Downregulation of AMPK accompanies leucine- and glucose-induced increases in protein synthesis and insulin resistance in rat skeletal muscle.AMPK 的下调伴随着亮氨酸和葡萄糖诱导的大鼠骨骼肌蛋白质合成和胰岛素抵抗的增加。
Diabetes. 2010 Oct;59(10):2426-34. doi: 10.2337/db09-1870. Epub 2010 Aug 3.
4
Rapamycin and quasi-programmed aging: four years later.雷帕霉素与准程序老化：四年之后。
Cell Cycle. 2010 May 15;9(10):1859-62. doi: 10.4161/cc.9.10.11872.
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8
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Nature. 2009 Jul 16;460(7253):392-5. doi: 10.1038/nature08221. Epub 2009 Jul 8.
9
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