Messing E M, Stamey T A
Urology. 1978 Oct;12(4):381-92. doi: 10.1016/0090-4295(78)90286-8.
In a retrospective review, 52 patients with interstitial cystitis have been studied. Patients with persistent lower tract irritative symptoms, repeatedly sterile urine, and negative urine cytology must be suspected of having interstitial cystitis, and a diagnosis of urethral syndrome in such patients is highly questionable until cystoscopy under anesthesia has been performed. We believe that the finding of multiple petechia-like hemorrhages (glomerulations) on the second distention of the bladder is the hallmark of interstitial cystitis, and that a reduced bladder capacity and a Hunner's ulcer represent a different (classic) stage of this disease. In all stages, the characteristic histologic finidng is submucosal edema and vasodilation. The presence of eosinophils and mast cells is variable, and even in the classic disease the muscularis often appears to be normal. Immuno fluorescent studies and laboratory tests, including the fluorescent antinuclear antibody test (FANA), have not helped us to diagnose (or investigate) interstitial cystitis. Bladder instillations with a 0.4 per cent solution of oxychlorosene sodium (Clorpactin WCS-90) have provided remarkable relief for many patients with this disease, particulary those with the classic form.
在一项回顾性研究中，对52例间质性膀胱炎患者进行了研究。对于存在持续性下尿路刺激症状、多次尿培养无菌且尿细胞学检查阴性的患者，必须怀疑患有间质性膀胱炎，在此类患者中，在进行麻醉下膀胱镜检查之前，诊断为尿道综合征是极可疑的。我们认为，膀胱第二次扩张时发现多个瘀点样出血（肾小球样变）是间质性膀胱炎的标志，膀胱容量减少和Hunner溃疡代表该病的不同（典型）阶段。在所有阶段，特征性的组织学表现是黏膜下水肿和血管扩张。嗜酸性粒细胞和肥大细胞的存在情况不一，即使在典型疾病中，肌层通常看起来也正常。免疫荧光研究和实验室检查，包括荧光抗核抗体试验（FANA），对我们诊断（或研究）间质性膀胱炎并无帮助。用0.4%的次氯酸钠溶液（氯胺T WCS - 90）膀胱灌注为许多患有这种疾病的患者，尤其是那些患有典型形式的患者，带来了显著缓解。
