Callahan J E, Herman A, Kappler J W, Marrack P
Department of Biochemistry, University of Colorado Health Sciences Center, Denver 80262.
J Immunol. 1990 Apr 1;144(7):2473-9.
The Staphylococcus aureus enterotoxins are known to be potent T cell activators, stimulating cell proliferation and lymphokine production. Two additional S. aureus proteins, exfoliating toxin and toxic shock syndrome toxin, share these properties. Recently these molecules have been termed "super-antigens" because of their ability to bind to class II MHC molecules and thus form ligands that interact with TCR in an unconventional manner. In this paper we show that each toxin stimulates mouse T cells bearing receptors that include particular V beta regions, almost regardless of the other variable receptor components. In addition, different toxins have different specificities for V beta.
已知金黄色葡萄球菌肠毒素是强效的T细胞激活剂，可刺激细胞增殖和淋巴因子产生。另外两种金黄色葡萄球菌蛋白，即剥脱毒素和中毒性休克综合征毒素，也具有这些特性。最近，由于这些分子能够结合II类主要组织相容性复合体（MHC）分子，并因此以非传统方式形成与T细胞受体（TCR）相互作用的配体，它们被称为“超抗原”。在本文中，我们表明每种毒素都能刺激带有特定Vβ区域受体的小鼠T细胞，几乎与其他可变受体成分无关。此外，不同毒素对Vβ具有不同的特异性。
