William S. Rowe Division of Rheumatology & Lupus Center, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA.
Nat Rev Rheumatol. 2011 Apr;7(4):225-33. doi: 10.1038/nrrheum.2011.15. Epub 2011 Mar 8.
Systemic lupus erythematosus (SLE) results from complex abnormalities of the innate and acquired immune systems. For reasons that are currently not well understood, the disease course and phenotype associated with SLE, although quite variable, are generally more severe when the diagnosis is made during childhood. Active disease, infections, lupus nephritis, and neuropsychiatric SLE manifestations are associated with higher morbidity and mortality. Unlike in adult-onset SLE, systemic glucocorticoid therapy and immunosuppressive medications are needed for the treatment of the majority of children and adolescents with SLE. The complex nature of childhood-onset SLE demands a comprehensive, multidisciplinary management approach that considers the patients' growth and development, their educational needs, and the unpredictable course of SLE and its complications.
系统性红斑狼疮（SLE）是由先天和获得性免疫系统的复杂异常引起的。由于目前尚不清楚的原因，尽管 SLE 的疾病过程和表型差异很大，但当儿童时期诊断时，通常更为严重。活动期疾病、感染、狼疮肾炎和神经精神性 SLE 表现与更高的发病率和死亡率相关。与成人发病的 SLE 不同，大多数儿童和青少年 SLE 患者需要全身性糖皮质激素治疗和免疫抑制药物治疗。儿童发病的 SLE 的复杂性需要一种全面的、多学科的管理方法，该方法需要考虑患者的生长和发育、他们的教育需求以及 SLE 及其并发症的不可预测的病程。
