[羟基脲诱发真性红细胞增多症腿部溃疡]
[Hydroxyurea induced-leg ulcer in polycythemia vera].
作者信息
Khaled Aida, El Guellali Nadia, Aissaoui Lamia, Robbana Feriel, Ezzine Nadia, Fazaa Becima, Kamoun Mohamed Ridha
机构信息
Service de Dermatologie, Hôpital Charles Nicolle de Tunis, Université Tunis El Manar, Tunis, Tunisie.
出版信息
Tunis Med. 2011 Mar;89(3):292-4.
BACKGROUND
Hydroxyurea (HU) is an antineoplastic drug commonly used to treat chronic myeloproliferative disorders. Dermatological side effects are frequent and usually benign. Leg ulceration following HU therapy is less common.
AIM
To describe epidemioclinical and therapeutic features of leg ulcers induced by HU.
CASE REPORT
A 70-year-old woman is treated with hydroxyurea for polycythemia vera. One year later; she presented with a malleolar painful ulcer, initially healed without discontinuation of the treatment, but has been recurred 2 months later, becoming multiple and bilateral. HU has been discontinued and ulcers were completely cured.
CONCLUSION
Leg ulcers induced by hydroxyurea are rare. Pathogenesis of HU-induced ulcers remains unknown and is multi factorial. Discontinuation of treatment is still the option of choice for complete recovery.
背景
羟基脲（HU）是一种常用于治疗慢性骨髓增殖性疾病的抗肿瘤药物。皮肤副作用很常见且通常为良性。HU治疗后出现腿部溃疡较少见。
目的
描述HU所致腿部溃疡的流行病学临床及治疗特征。
病例报告
一名70岁女性因真性红细胞增多症接受羟基脲治疗。一年后，她出现踝关节处疼痛性溃疡，最初在未中断治疗的情况下愈合，但2个月后复发，且变为多发和双侧性。已停用HU，溃疡完全治愈。
结论
羟基脲所致腿部溃疡罕见。HU诱导溃疡的发病机制尚不清楚且是多因素的。停药仍是实现完全康复的首选方案。
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