Steels E, Heenen M, Germaux M A, Moens J P
Service de Dermatologie, Hôpital Erasme, CHIREC, Site Edith Cavell.
Rev Med Brux. 2006 Jan-Feb;27(1):39-41.
Hydroxyurea is an antitumour agent used most commonly to treat myeloproliferative disorders. We present a clinical observation illustrating different cutaneous side effects susceptible to occur during a long-term treatment by hydroxyurea : leg ulceration, oral ulcer and spinocellular carcinoma. This clinical observation is completed by a review of the literature published on the cutaneous side effects of hydroxyurea treatment.
羟基脲是一种最常用于治疗骨髓增殖性疾病的抗肿瘤药物。我们展示了一项临床观察，阐述了在羟基脲长期治疗期间可能出现的不同皮肤副作用：腿部溃疡、口腔溃疡和棘细胞癌。通过对已发表的关于羟基脲治疗皮肤副作用的文献综述，完善了这一临床观察。
