Bueno-Nava A, Gonzalez-Pina R, Avila-Luna A, Alfaro-Rodriguez A
Instituto Nacional de Rehabilitacion, SSA, Mexico DF, Mexico.
Rev Neurol. 2011 Mar 16;52(6):371-7.
The basal ganglia include the striatum, globus pallidus, the substantia nigra pars compacta and pars reticulata. The striatum receives afferent input from the substantia nigra pars compacta. The principal neurons of the striatum are medium spiny neurons, that express high levels of D1 and D2 receptors.
This review deals about the aspects underlying to the negative feedback via long-loop in the striatal dopamine release modulation in the rat. Also, the motor function in dopamine receptor knock-out mice is discussed.
The intrastriatal infusion and systemic injection of dopamine receptor agonists and antagonists may regulate the striatal dopamine release and induce changes in motor function. Disruption of the D1 and D2 gene shown that the motor function is controlled by D1 and D2 receptors. The study of the long-loop negative feedback may contribute to our understanding in the physiology and dysfunction of basal ganglia.
基底神经节包括纹状体、苍白球、黑质致密部和黑质网状部。纹状体接受来自黑质致密部的传入输入。纹状体的主要神经元是中等棘状神经元，其表达高水平的D1和D2受体。
本综述探讨大鼠纹状体多巴胺释放调节中长环负反馈的潜在机制。此外，还讨论了多巴胺受体敲除小鼠的运动功能。
纹状体内注入和全身注射多巴胺受体激动剂和拮抗剂可调节纹状体多巴胺释放并诱导运动功能改变。D1和D2基因的破坏表明运动功能受D1和D2受体控制。对长环负反馈的研究可能有助于我们理解基底神经节的生理学和功能障碍。
