Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
NMR Biomed. 2011 Dec;24(10):1253-63. doi: 10.1002/nbm.1685. Epub 2011 Mar 8.
A method is presented which allows for the accurate extraction of regional functional metrics in rodent lungs using hyperpolarized gas. The technique is based on the combination of measured T(1) decay, an independent measure of specific ventilation and mass balance considerations to extract the regional oxygen levels and uptake. In phantom and animal experiments, it is demonstrated that the redistribution of gas during the measurement is a significant confounding factor, and this effect is addressed analytically. The resulting parameterization of gas flow increases the accuracy of oxygen-sensitive MRI, and may also be used independently to assess air trapping and airway constriction. Limitations of the technique with respect to spatial resolution and robustness are also discussed.
本文提出了一种方法，可使用超极化气体准确提取啮齿动物肺部的区域性功能指标。该技术基于测量的 T1 衰减（比通气的独立测量）和质量平衡考虑的组合，以提取区域氧水平和摄取量。在体模和动物实验中，证明了测量过程中气体的再分配是一个重要的混杂因素，并且对此效应进行了分析。对气体流量的这种参数化处理提高了氧敏感 MRI 的准确性，也可独立用于评估空气滞留和气道收缩。还讨论了该技术在空间分辨率和稳健性方面的局限性。
