基于癌杀菌素-DnaK复合物的高分辨率结构，合理设计具有卓越蛋白酶稳定性和抗菌活性的癌杀菌素衍生物。 - Suppr

Rational design of oncocin derivatives with superior protease stabilities and antibacterial activities based on the high-resolution structure of the oncocin-DnaK complex.

作者信息

Knappe Daniel, Zahn Michael, Sauer Ute, Schiffer Guido, Sträter Norbert, Hoffmann Ralf

机构信息

Institut für Bioanalytische Chemie, Biotechnologisch-Biomedizinisches Zentrum, Fakultät für Chemie und Mineralogie, Universität Leipzig, Leipzig, Germany.

出版信息

Chembiochem. 2011 Apr 11;12(6):874-6. doi: 10.1002/cbic.201000792. Epub 2011 Mar 8.

DOI:10.1002/cbic.201000792

PMID:21387510

Abstract

摘要

相似文献

Rational design of oncocin derivatives with superior protease stabilities and antibacterial activities based on the high-resolution structure of the oncocin-DnaK complex.

Chembiochem. 2011 Apr 11;12(6):874-6. doi: 10.1002/cbic.201000792. Epub 2011 Mar 8.

Bactericidal oncocin derivatives with superior serum stabilities.

Int J Antimicrob Agents. 2011 Feb;37(2):166-70. doi: 10.1016/j.ijantimicag.2010.10.028. Epub 2010 Dec 23.

Crystal structure of a thermophilic GrpE protein: insight into thermosensing function for the DnaK chaperone system.

J Mol Biol. 2010 Mar 5;396(4):1000-11. doi: 10.1016/j.jmb.2009.12.028. Epub 2009 Dec 28.

Conformational properties of bacterial DnaK and yeast mitochondrial Hsp70. Role of the divergent C-terminal alpha-helical subdomain.

FEBS J. 2005 Jun;272(12):3184-96. doi: 10.1111/j.1742-4658.2005.04737.x.

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Determinants of recombinant production of antimicrobial cationic peptides and creation of peptide variants in bacteria.

Biochem Biophys Res Commun. 1998 Jun 29;247(3):674-80. doi: 10.1006/bbrc.1998.8848.

The insect antimicrobial peptide, L-pyrrhocoricin, binds to and stimulates the ATPase activity of both wild-type and lidless DnaK.

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NMR solution structure of the 21 kDa chaperone protein DnaK substrate binding domain: a preview of chaperone-protein interaction.

Biochemistry. 1998 Jun 2;37(22):7929-40. doi: 10.1021/bi9800855.

A linguistic model for the rational design of antimicrobial peptides.

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Sequence requirements and an optimization strategy for short antimicrobial peptides.

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Rational design of oncocin derivatives with superior protease stabilities and antibacterial activities based on the high-resolution structure of the oncocin-DnaK complex.

作者信息

Knappe Daniel, Zahn Michael, Sauer Ute, Schiffer Guido, Sträter Norbert, Hoffmann Ralf

机构信息

Institut für Bioanalytische Chemie, Biotechnologisch-Biomedizinisches Zentrum, Fakultät für Chemie und Mineralogie, Universität Leipzig, Leipzig, Germany.

出版信息

Chembiochem. 2011 Apr 11;12(6):874-6. doi: 10.1002/cbic.201000792. Epub 2011 Mar 8.

DOI:10.1002/cbic.201000792

PMID:21387510

Abstract

摘要

相似文献

Rational design of oncocin derivatives with superior protease stabilities and antibacterial activities based on the high-resolution structure of the oncocin-DnaK complex.

Chembiochem. 2011 Apr 11;12(6):874-6. doi: 10.1002/cbic.201000792. Epub 2011 Mar 8.

Bactericidal oncocin derivatives with superior serum stabilities.

Int J Antimicrob Agents. 2011 Feb;37(2):166-70. doi: 10.1016/j.ijantimicag.2010.10.028. Epub 2010 Dec 23.

Crystal structure of a thermophilic GrpE protein: insight into thermosensing function for the DnaK chaperone system.

J Mol Biol. 2010 Mar 5;396(4):1000-11. doi: 10.1016/j.jmb.2009.12.028. Epub 2009 Dec 28.

Conformational properties of bacterial DnaK and yeast mitochondrial Hsp70. Role of the divergent C-terminal alpha-helical subdomain.

FEBS J. 2005 Jun;272(12):3184-96. doi: 10.1111/j.1742-4658.2005.04737.x.

Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against gram-negative human pathogens.

J Med Chem. 2010 Jul 22;53(14):5240-7. doi: 10.1021/jm100378b.

Determinants of recombinant production of antimicrobial cationic peptides and creation of peptide variants in bacteria.

Biochem Biophys Res Commun. 1998 Jun 29;247(3):674-80. doi: 10.1006/bbrc.1998.8848.

The insect antimicrobial peptide, L-pyrrhocoricin, binds to and stimulates the ATPase activity of both wild-type and lidless DnaK.

FEBS Lett. 2004 May 7;565(1-3):65-9. doi: 10.1016/j.febslet.2004.03.075.

NMR solution structure of the 21 kDa chaperone protein DnaK substrate binding domain: a preview of chaperone-protein interaction.

Biochemistry. 1998 Jun 2;37(22):7929-40. doi: 10.1021/bi9800855.

A linguistic model for the rational design of antimicrobial peptides.

Nature. 2006 Oct 19;443(7113):867-9. doi: 10.1038/nature05233.

Sequence requirements and an optimization strategy for short antimicrobial peptides.

Chem Biol. 2006 Oct;13(10):1101-7. doi: 10.1016/j.chembiol.2006.08.014.

引用本文的文献

Comparative evaluation of antimicrobial peptides: effect on formation, metabolic activity and viability of biofilms.

Front Microbiol. 2025 Apr 11;16:1548362. doi: 10.3389/fmicb.2025.1548362. eCollection 2025.

Explainable deep learning and virtual evolution identifies antimicrobial peptides with activity against multidrug-resistant human pathogens.

Nat Microbiol. 2025 Feb;10(2):332-347. doi: 10.1038/s41564-024-01907-3. Epub 2025 Jan 17.

Proline-Rich Antimicrobial Peptides from Invertebrates.

Molecules. 2024 Dec 12;29(24):5864. doi: 10.3390/molecules29245864.

Stereorandomized Oncocins with Preserved Ribosome Binding and Antibacterial Activity.

J Med Chem. 2024 Nov 14;67(21):19448-19459. doi: 10.1021/acs.jmedchem.4c01768. Epub 2024 Oct 24.

Peptide-based molecules for the disruption of bacterial Hsp70 chaperones.

Curr Opin Chem Biol. 2023 Oct;76:102373. doi: 10.1016/j.cbpa.2023.102373. Epub 2023 Jul 27.

In Vitro Properties and Pharmacokinetics of Temporarily PEGylated Onc72 Prodrugs.

Adv Healthc Mater. 2023 Apr;12(11):e2202368. doi: 10.1002/adhm.202202368. Epub 2023 Jan 20.

Multiple roles of ribosomal antimicrobial peptides in tackling global antimicrobial resistance.

R Soc Open Sci. 2022 Jan 26;9(1):211583. doi: 10.1098/rsos.211583. eCollection 2022 Jan.

Effect of Amino Acid Substitutions on 70S Ribosomal Binding, Cellular Uptake, and Antimicrobial Activity of Oncocin Onc112.

Chembiochem. 2022 Mar 4;23(5):e202100609. doi: 10.1002/cbic.202100609. Epub 2022 Jan 12.

Antimicrobial Peptides: An Update on Classifications and Databases.

Int J Mol Sci. 2021 Oct 28;22(21):11691. doi: 10.3390/ijms222111691.

Translocation of non-lytic antimicrobial peptides and bacteria penetrating peptides across the inner membrane of the bacterial envelope.

Curr Genet. 2022 Feb;68(1):83-90. doi: 10.1007/s00294-021-01217-9. Epub 2021 Nov 8.

Rational design of oncocin derivatives with superior protease stabilities and antibacterial activities based on the high-resolution structure of the oncocin-DnaK complex.

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Rational design of oncocin derivatives with superior protease stabilities and antibacterial activities based on the high-resolution structure of the oncocin-DnaK complex.

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