D'Alessandro Vito, Greco Antonio, Clemente Celeste, Sperandeo Marco, De Cata Angelo, Di Micco Concetta, Maiello Evaristo, Vendemiale Gianluigi
Unit of Internal Medicine, IRCCS Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo, Italy.
Tumori. 2010 Nov-Dec;96(6):1040-3.
Tumor lysis syndrome has been observed in patients with bulky, treatment-sensitive tumors, in particular hematological malignancies, especially after medical treatment (chemotherapy, corticosteroids, radiation, hormonal agents, and biological response modifiers). Tumor lysis syndrome has been observed also in solid malignancies and it very rarely occurs spontaneously. Tumor lysis syndrome-associated metabolic abnormalities include hyperuricemia, hyperphosphatemia, hyperkalemia, hypocalcemia and uremia. Severe hypoglycemia is another rare metabolic disorder, uncommonly associated with solid malignancies. The case described here is peculiar for the abrupt onset of these two rare conditions in a patient with a metastatic germ cell tumor.
肿瘤溶解综合征已在患有体积较大、对治疗敏感的肿瘤患者中观察到，尤其是血液系统恶性肿瘤，特别是在接受医学治疗（化疗、皮质类固醇、放疗、激素制剂和生物反应调节剂）后。肿瘤溶解综合征也在实体恶性肿瘤中被观察到，且极少自发发生。与肿瘤溶解综合征相关的代谢异常包括高尿酸血症、高磷血症、高钾血症、低钙血症和尿毒症。严重低血糖是另一种罕见的代谢紊乱，很少与实体恶性肿瘤相关。本文所述病例的特殊之处在于，一名转移性生殖细胞肿瘤患者突然同时出现了这两种罕见病症。
