Alaigh Vivek, Datta Debapriya
Department of Medicine, University of CT Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA.
Division of Pulmonary-Critical Care Medicine, University of CT Health Center, Farmington, CT 06030, USA.
Case Rep Crit Care. 2017;2017:4141287. doi: 10.1155/2017/4141287. Epub 2017 Sep 11.
Tumor lysis syndrome (TLS) is an oncologic emergency characterized by a combination of metabolic derangements (hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia) caused by rapid turnover from cell destruction in certain cancers. These metabolic derangements can lead to seizures, cardiac arrhythmias, renal failure, and death. TLS is usually seen after the initiation of chemotherapy for hematologic malignancies. TLS occurring spontaneously, without initiation of chemotherapy, is rare and its occurrence in solid tumors is rarer still. We report a case of spontaneous TLS in a patient with leiomyosarcoma of the uterus, with metastasis to lung. Such a case has never been reported before.
肿瘤溶解综合征（TLS）是一种肿瘤急症，其特征是某些癌症中细胞破坏导致的快速代谢转换所引起的一系列代谢紊乱（高尿酸血症、高钾血症、高磷血症和低钙血症）。这些代谢紊乱可导致癫痫发作、心律失常、肾衰竭和死亡。TLS通常在血液系统恶性肿瘤化疗开始后出现。未经化疗而自发发生的TLS很罕见，在实体瘤中发生则更为罕见。我们报告一例子宫平滑肌肉瘤伴肺转移患者发生自发TLS的病例。此前从未有过此类病例的报道。
