Brah S, Thomas G, Chapon F, Franques J, Jourde N, Harlé J-R, Durand J-M, Jean R, Chiche L
Service de médecine interne, hôpital universitaire de la Conception, 147, boulevard Baille, 13005 Marseille, France.
Rev Med Interne. 2012 Feb;33(2):e10-3. doi: 10.1016/j.revmed.2011.02.006. Epub 2011 Mar 8.
Cerebral aneurysms secondary to cerebral vasculitis related to systemic lupus erythematosus are rare. We report a 31-year-old woman who presented with a lupus flare associated with inaugural generalized seizures. Computed tomography angiography showed subarachnoid hemorrhage by rupture of a cerebellar artery fusiform aneurysm. Later, despite the initiation of corticosteroids and cyclophosphamide, she presented a second cerebral hemorrhage due to the rupture of a new aneurysm in lenticulostriates arteries. The outcome was fatal. We discuss the frequency and management of this severe complication of systemic lupus erythematosus.
系统性红斑狼疮相关的脑血管炎继发的脑动脉瘤很罕见。我们报告一名31岁女性,她因首次全身性癫痫发作而出现狼疮病情活动。计算机断层血管造影显示小脑动脉梭形动脉瘤破裂导致蛛网膜下腔出血。后来,尽管开始使用了皮质类固醇和环磷酰胺,但她因豆纹动脉新动脉瘤破裂而出现了第二次脑出血。结果是致命的。我们讨论了系统性红斑狼疮这种严重并发症的发生率及处理。