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儿童注意缺陷多动障碍患者静脉导管插入时唾液皮质醇反应性。

Salivary cortisol responsivity to an intravenous catheter insertion in children with attention-deficit/hyperactivity disorder.

机构信息

College of Nursing, University of Iowa, Iowa City, IA 52242, USA.

出版信息

J Pediatr Psychol. 2011 Sep;36(8):902-10. doi: 10.1093/jpepsy/jsr012. Epub 2011 Mar 9.

DOI:10.1093/jpepsy/jsr012
PMID:21389037
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3202938/
Abstract

OBJECTIVE

To compare salivary cortisol baseline levels and responsivity as well as behavioral distress to intravenous (IV) catheter insertions in 4- to 10-year-old children with (n = 29) and without (n = 339) attention-deficit/hyperactivity disorder (ADHD).

METHODS

This is a secondary data analysis from a sample of 542 children who participated in a multisite study on distraction. Data included were demographic variables, Pediatric Behavior Scale-30, Observational Scale of Behavioral Distress-Revised, and four salivary cortisol samples.

RESULTS

Home samples from the ADHD group revealed nonsignificant but higher cortisol levels than the non-ADHD group. However, on the clinic day, the ADHD group had significantly lower cortisol levels before (0.184 vs. 0.261, p = .040) and 20-30 min after IV insertion (0.186 vs. 0.299, p = .014) compared with the non-ADHD group.

CONCLUSIONS

Cortisol levels in children with and without ADHD differ in response to the stress of an IV insertion.

摘要

目的

比较 4 至 10 岁儿童中患有（n=29）和不患有（n=339）注意缺陷多动障碍（ADHD）的儿童静脉（IV）导管插入术时唾液皮质醇基线水平和反应性以及行为困扰。

方法

这是对 542 名儿童参加分心多中心研究的样本进行的二次数据分析。数据包括人口统计学变量、儿科行为量表-30、行为困扰观察量表修订版和四个唾液皮质醇样本。

结果

ADHD 组的家庭样本显示皮质醇水平虽无显著差异但高于非 ADHD 组。然而，在就诊日，ADHD 组在 IV 插入前（0.184 与 0.261，p=0.040）和 20-30 分钟后（0.186 与 0.299，p=0.014）的皮质醇水平显著低于非 ADHD 组。

结论

ADHD 儿童和非 ADHD 儿童对 IV 插入应激的皮质醇水平反应不同。

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本文引用的文献

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Factors explaining children's responses to intravenous needle insertions.解释儿童对静脉穿刺反应的因素。
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Cortisol and externalizing behavior in children and adolescents: mixed meta-analytic evidence for the inverse relation of basal cortisol and cortisol reactivity with externalizing behavior.儿童和青少年的皮质醇与外化行为：关于基础皮质醇及皮质醇反应性与外化行为呈负相关关系的混合元分析证据
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