Randazzo William T, Dockray Samantha, Susman Elizabeth J
The Pennsylvania State University, University Park, PA, USA.
Child Psychiatry Hum Dev. 2008 Mar;39(1):27-38. doi: 10.1007/s10578-007-0068-3. Epub 2007 Jun 13.
To investigate the hypothalamic pituitary adrenal (HPA) axis response to a stressor in adolescents with inattentive type attention-deficit hyperactivity disorder symptoms (ADHD-I).
Salivary cortisol was measured in threshold inattentive (TI, n = 7), moderately inattentive (MI, n = 13) and no symptom (comparison) (n = 19) groups of healthy, young adolescents, based on symptom counts, prior to and after an induced social/cognitive stressor.
The TI group displayed a significant decrease in cortisol post stressor whereas both the MI and comparison groups showed an increase in cortisol.
The diagnostic threshold of inattentive type ADHD shows HPA axis dysregulation whereas the more mild form does not show dysfunction.
研究注意力不集中型注意力缺陷多动障碍症状（ADHD-I）青少年下丘脑-垂体-肾上腺（HPA）轴对应激源的反应。
根据症状计数，在诱发社会/认知应激源之前和之后，对健康的年轻青少年的阈下注意力不集中（TI，n = 7）、中度注意力不集中（MI，n = 13）和无症状（对照组）（n = 19）组测量唾液皮质醇。
TI组在应激源后皮质醇显著降低，而MI组和对照组皮质醇均升高。
注意力不集中型ADHD的诊断阈值显示HPA轴调节异常，而症状较轻的形式未显示功能障碍。
