Department of Chemistry, University of North Carolina, Chapel Hill, NC 27599, USA.
Sci Transl Med. 2011 Mar 9;3(73):73ps8. doi: 10.1126/scitranslmed.3002137.
When treating metastatic tumors, chemoresistance can cause problems. A report in this issue of Science Translational Medicine demonstrates the potential of nanodiamond carriers (2 to 8 nanometers) for treating cancers with drug-efflux-based chemoresistance. Nanodiamond-mediated delivery of the chemotherapeutic doxorubicin (Dox) allowed for prolonged activity and increased apoptosis with decreased toxicity when compared with free Dox in liver cancer cells in culture as well as in vivo in mouse liver tumors. This finding may represent a broadly applicable strategy for overcoming adenosine 5'-triphosphate (ATP)-binding cassette (ABC) drug transporter-mediated resistance during cancer chemotherapy.
在治疗转移性肿瘤时，化疗耐药性可能会导致问题。本期《科学转化医学》杂志的一篇报道展示了纳米金刚石载体（2 至 8 纳米）在治疗基于药物外排的化疗耐药性癌症方面的潜力。与游离阿霉素（Dox）相比，纳米金刚石介导的化疗药物多柔比星（Dox）的递呈可延长其在肝癌细胞培养物和小鼠肝肿瘤中的活性，并增加细胞凋亡，同时降低毒性。这一发现可能代表了一种广泛适用的策略，可以克服癌症化疗过程中腺苷 5'-三磷酸（ATP）结合盒（ABC）药物转运蛋白介导的耐药性。
