Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.
Angew Chem Int Ed Engl. 2013 Jun 24;52(26):6580-9. doi: 10.1002/anie.201209145. Epub 2013 May 13.
Particle replication in nonwetting templates (PRINT) is a continuous, roll-to-roll, high-resolution molding technology which allows the design and synthesis of precisely defined micro- and nanoparticles. This technology adapts the lithographic techniques from the microelectronics industry and marries these with the roll-to-roll processes from the photographic film industry to enable researchers to have unprecedented control over particle size, shape, chemical composition, cargo, modulus, and surface properties. In addition, PRINT is a GMP-compliant (GMP=good manufacturing practice) platform amenable for particle fabrication on a large scale. Herein, we describe some of our most recent work involving the PRINT technology for application in the biomedical and material sciences.
无液模板中的粒子复制（PRINT）是一种连续的、卷对卷的、高分辨率的成型技术，可用于设计和合成精确定义的微纳米粒子。该技术采用微电子工业中的光刻技术，并将其与照相胶片工业中的卷对卷工艺相结合，使研究人员能够对粒子的大小、形状、化学组成、有效载荷、模量和表面性能进行前所未有的控制。此外，PRINT 是一种符合 GMP（良好生产规范）的平台，适用于大规模的粒子制造。本文介绍了我们最近在生物医学和材料科学领域应用 PRINT 技术的一些工作。
