抗胆碱能药物对澳大利亚老年人认知功能的影响：来自 AIBL 研究的结果。

Effects of anticholinergic drugs on cognitive function in older Australians: results from the AIBL study.

机构信息

Department of Psychiatry, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

出版信息

Dement Geriatr Cogn Disord. 2011;31(3):173-8. doi: 10.1159/000325171. Epub 2011 Mar 9.

Abstract

BACKGROUND/AIMS: The nature and extent of adverse cognitive effects due to the prescription of anticholinergic drugs in older people with and without dementia is unclear.

METHODS

We calculated the anticholinergic load (ACL) of medications taken by participants of the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of ageing, a cohort of 211 Alzheimer's disease (AD) patients, 133 mild cognitive impairment (MCI) patients and 768 healthy controls (HC) all aged over 60 years. The association between ACL and cognitive function was examined for each diagnostic group (HC, MCI, AD).

RESULTS

A high ACL within the HC group was associated with significantly slower response speeds for the Stroop color and incongruent trials. No other significant relationships between ACL and cognition were noted.

CONCLUSION

In this large cohort, prescribed anticholinergic drugs appeared to have modest effects upon psychomotor speed and executive function, but not on other areas of cognition in healthy older adults.

摘要

背景/目的：由于抗胆碱能药物在有和没有痴呆的老年人中的处方，其导致的不良认知影响的性质和程度尚不清楚。

方法

我们计算了澳大利亚成像、生物标志物和生活方式（AIBL）老化研究参与者所服用药物的抗胆碱能负荷（ACL），该研究为一个队列，包括 211 名阿尔茨海默病（AD）患者、133 名轻度认知障碍（MCI）患者和 768 名健康对照（HC），所有患者年龄均在 60 岁以上。检查了 ACL 与每个诊断组（HC、MCI、AD）的认知功能之间的关联。