Chih-Ching Chang, Department of Environmental and Occupational Health, National Cheng Kung University, Tainan 70154, Taiwan, China.
World J Gastroenterol. 2011 Feb 14;17(6):784-8. doi: 10.3748/wjg.v17.i6.784.
To examine the association between parity and gastric cancer (the cases are almost all premenopausal women) risk in a cohort of young parous women.
The study cohort consisted of all women with a record of a first and singleton childbirth in the Birth Register between 1978 and 1987. We tracked each woman from the time of her first childbirth to December 31, 2008. Their vital status was ascertained by linking records to the computerized mortality database. Cox proportional hazard regression models were used to estimate hazard ratios of death from gastric cancer associated with parity.
There were 1090 gastric cancer deaths (85.87% of them were premenopausal) during 33 686 828 person-years of follow-up. The mortality rate of gastric cancer was 3.24 cases per 100,000 person-years. A trend of increasing risk of gastric cancer was seen with increasing parity. The adjusted hazard ratio was 1.24 [confidence interval (95% CI): 1.02-1.50] for women who had borne two to three children, and 1.32 (95% CI: 1.01-1.72) for women with four or more births, when compared with women who had given birth to only one child.
These results suggest that higher parity may increase the risk of death from gastric cancer among premenopausal women.
在年轻多产妇队列中研究生育次数与胃癌（病例几乎均为绝经前女性）风险之间的关联。
研究队列由 1978 年至 1987 年出生登记册中首次分娩和单胎分娩记录的所有女性组成。我们从每位女性首次分娩开始追踪，直至 2008 年 12 月 31 日。通过将记录与计算机化死亡率数据库相关联，确定她们的生存状态。使用 Cox 比例风险回归模型来估计与生育次数相关的胃癌死亡的风险比。
在 33686828 人年的随访期间，有 1090 例胃癌死亡（其中 85.87%为绝经前）。胃癌的死亡率为每 100000 人年 3.24 例。随着生育次数的增加，胃癌的发病风险呈上升趋势。与仅生育一个孩子的女性相比，生育两个至三个孩子的女性调整后的风险比为 1.24（95%可信区间：1.02-1.50），生育四个或更多孩子的女性为 1.32（95%可信区间：1.01-1.72）。
这些结果表明，生育次数增加可能会增加绝经前女性死于胃癌的风险。
