[血清素与下丘脑对饥饿的控制：综述]

[Serotonin and hypothalamic control of hunger: a review].

作者信息

Feijó Fernanda de Matos, Bertoluci Marcello Casaccia, Reis Cíntia

机构信息

Programa de Pós-Graduação em Medicina, Universidade Federal do Rio Grando de Sul, Porto Alegre, RS.

出版信息

Rev Assoc Med Bras (1992). 2011 Jan-Feb;57(1):74-7.

PMID:21390463

Abstract

This paper reviews involvement of the serotonergic system in the control of food intake and satiety. It is of great interest to understand the relevance of this system for physiological control of energy balance and obesity. Over 35 years of research suggest that serotonin (5-HT) plays an important role in satiety. Thus, the serotonergic system has been a viable target for weight control. The 5-HT has control over hunger and satiety through different receptors with distinct functions. The 5-HT2C receptor may be more important in the relationship between food intake and energy balance. This review will discuss the mechanisms of the serotonergic system involved in the control of food intake and satiety.

摘要

本文综述了血清素能系统在食物摄入和饱腹感控制中的作用。了解该系统与能量平衡和肥胖的生理控制之间的相关性具有重要意义。超过35年的研究表明，血清素（5-羟色胺，5-HT）在饱腹感中起重要作用。因此，血清素能系统一直是体重控制的一个可行靶点。5-HT通过具有不同功能的不同受体控制饥饿和饱腹感。5-HT2C受体在食物摄入与能量平衡的关系中可能更为重要。本综述将讨论血清素能系统参与食物摄入和饱腹感控制的机制。