两种不同的细胞蛋白与腺病毒早期启动子的EIa反应元件相互作用。
Two distinct cellular proteins interact with the EIa-responsive element of an adenovirus early promoter.
作者信息
Jansen-Durr P, Wintzerith M, Reimund B, Hauss C, Kédinger C
机构信息
Laboratoire de Génétique Moléculaire des Eucaryotes du Centre National de la Recherche Scientifique, Faculté de Médecine, Strasbourg, France.
出版信息
J Virol. 1990 May;64(5):2384-7. doi: 10.1128/JVI.64.5.2384-2387.1990.
EIa-dependent transactivation of the adenovirus EIIa early (EIIaE) promoter is correlated with the activation of the cellular transcription factor E2F. In this study we identified a cellular protein, C alpha, that is distinct from E2F and that binds two sites in the EIIaE promoter, one of which overlaps with the proximal E2F binding site of the EIIaE promoter. The possible involvement of C alpha in the EIa responsiveness of this promoter is discussed.
腺病毒EIIa早期（EIIaE）启动子的Ela依赖性反式激活与细胞转录因子E2F的激活相关。在本研究中，我们鉴定出一种细胞蛋白Cα，它不同于E2F，并且能结合EIIaE启动子中的两个位点，其中一个位点与EIIaE启动子的近端E2F结合位点重叠。本文讨论了Cα可能参与该启动子的Ela反应性。
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