Institute of Organic Chemistry, Catalysis and Petrochemistry, Slovak University of Technology, Radlinského 9, 81237 Bratislava, Slovak Republic.
J Org Chem. 2011 Apr 15;76(8):2613-8. doi: 10.1021/jo1024927. Epub 2011 Mar 10.
A tandem catalysis protocol based on decarboxylative coupling of alkynoic acids and 1,3-dipolar cycloaddition of azides enables a highly efficient synthesis of a variety of functionalized 1,2,3-triazoles. The three-step, one-pot method avoids usage of gaseous or highly volatile terminal alkynes, reduces handling of potentially unstable and explosive azides to a minimum, and furnishes target structures in excellent yields and a very good purity without the need for additional purification.
一种基于炔酸脱羧偶联和叠氮化物 1,3-偶极环加成的串联催化协议，能够高效合成各种功能化的 1,2,3-三唑。该三步一锅法避免了使用气态或高挥发性末端炔烃，将潜在不稳定和易爆叠氮化物的处理量降至最低，并以极好的收率和非常高的纯度提供目标结构，无需额外的纯化。
