Pall M L
Program in Genetics and Cell Biology, Washington State University, Pullman 99164-4350.
Mech Ageing Dev. 1990 Mar 15;52(2-3):287-94. doi: 10.1016/0047-6374(90)90132-y.
The natural death (nd) mutant of the fungus Neurospora crassa, unlike the wild-type, undergoes an aging process, which leads to the cessation of growth. It is shown here that the ATP/ADP ratio of the mutant declines with age to about 3:1 whereas other strains of Neurospora in the same growth medium maintain ratios of about 8 to 9:1. The decline in ATP/ADP ratio is not caused by the cessation of growth of the mutant. The results suggest, rather, that the cessation of growth may be caused, in part or in whole, by the defect in energy metabolism that produces the low ATP/ADP ratio. They support the hypothesis that defects in mitochondrial energy metabolism may be an important contributing factor to the aging process.
与野生型不同，粗糙脉孢菌的自然死亡（nd）突变体经历衰老过程，导致生长停止。本文表明，突变体的ATP/ADP比值随年龄增长下降至约3:1，而在相同生长培养基中的其他脉孢菌菌株保持约8至9:1的比值。ATP/ADP比值的下降不是由突变体生长停止引起的。相反，结果表明，生长停止可能部分或全部由产生低ATP/ADP比值的能量代谢缺陷引起。它们支持线粒体能量代谢缺陷可能是衰老过程的一个重要促成因素的假设。
