Servizio di Immunoematologia e Medicina Trasfusionale, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy.
Clin Chem Lab Med. 2011 Jun;49(6):967-70. doi: 10.1515/CCLM.2011.154. Epub 2011 Mar 11.
The low-density lipoprotein receptor-related protein 1 (LRP1) is a multifunctional cell surface receptor member of the low-density lipoprotein (LDL)-receptor family. As LRP1 plays an important role in endocytosis and regulation of signalling pathways, it is implicated in a number of physiologic processes, including the regulation of lipid metabolism, the proliferation of vascular smooth muscle cells and in neuro-development. More recently, LRP1 has been implicated in the catabolism of factor VIII and regulation of its plasma concentrations. The pathophysiology of the role of LRP1 in hemostasis will be summarized in this review.
低密度脂蛋白受体相关蛋白 1（LRP1）是一种多功能细胞表面受体，属于低密度脂蛋白（LDL）受体家族。由于 LRP1 在胞吞作用和信号通路调节中发挥重要作用，因此它与许多生理过程有关，包括脂质代谢的调节、血管平滑肌细胞的增殖以及神经发育。最近，LRP1 还参与了因子 VIII 的代谢和其血浆浓度的调节。本综述将总结 LRP1 在止血中的作用的病理生理学。
