Department of Obstetrics and Gynecology, Yuzuncu Yil University School of Medicine, Van, Turkey.
J Perinat Med. 2011 Jul;39(4):411-6. doi: 10.1515/jpm.2011.024. Epub 2011 Mar 11.
To investigate the expression of laminin receptor 1 (LR1), a non-integrin-type laminin receptor, in preeclamptic and normal third-trimester placentas, as well as to investigate whether its expression differs with disease severity.
Third trimester placental samples obtained from deliveries of preeclamptic (n=34) and normotensive healthy pregnant women (n=35) were immunohistochemically studied for the expression of LR1. The placentas from both mild (n=14) and severe (n=20) preeclamptic pregnancies were further assessed for strength of LR1 expression according to disease severity.
When compared with normal placentas, the staining with LR1 protein in cytotrophoblasts and syncytiotrophoblasts was lower in preeclamptic placentas (P<0.05 and P<0.01, respectively). The intensity of staining with LR1 in decidual cells, cytotrophoblasts, syncytiotrophoblasts, and extracellular matrix cells of preeclamptic placentas did not vary with disease severity (P>0.05).
Decreased LR1 expression in cytotrophoblasts and syncytiotrophoblasts of preeclamptic placentas, which may be independent of disease severity, might have a role in shallow trophoblastic invasion in preeclampsia.
研究层粘连蛋白受体 1（LR1）在子痫前期和正常妊娠晚期胎盘组织中的表达情况，并探讨其表达是否与疾病严重程度有关。
采用免疫组织化学方法研究 34 例子痫前期和 35 例正常妊娠晚期分娩的胎盘组织中 LR1 的表达。根据疾病严重程度，进一步评估轻度（n=14）和重度（n=20）子痫前期胎盘组织中 LR1 表达的强度。
与正常胎盘相比，子痫前期胎盘的滋养细胞和合体滋养细胞中 LR1 蛋白染色强度降低（P<0.05 和 P<0.01）。子痫前期胎盘蜕膜细胞、滋养细胞、合体滋养细胞和细胞外基质细胞中 LR1 的染色强度与疾病严重程度无关（P>0.05）。
子痫前期胎盘滋养细胞和合体滋养细胞中 LR1 表达减少，可能与疾病严重程度无关，这可能与子痫前期浅着床有关。
