白细胞介素-22 产生的 RORγt+先天淋巴细胞对上皮细胞功能的控制。
Control of epithelial cell function by interleukin-22-producing RORγt+ innate lymphoid cells.
机构信息
IMMH, University of Freiburg, Freiburg, Germany.
出版信息
Immunology. 2011 Apr;132(4):453-65. doi: 10.1111/j.1365-2567.2011.03410.x.
Abstract
It is rapidly emerging that the defence system of innate lymphocytes is more diverse than previously recognized. In addition to natural killer (NK) cells, lymphoid tissue inducer (LTi) cells, and natural helper cells have now been identified. LTi cells are developmentally dependent on the orphan transcription factor RORγt and instruct lymph node development during embryogenesis. More recently, it has become evident, that in addition to their role for lymph organ development, LTi cells are also potent producers of cytokines such as interleukin-22 (IL-22) and IL-17 in adult mice. In addition to LTi cells, another RORγt-dependent innate lymphocyte subset co-expressing RORγt and NK cell receptors (NKRs) has been identified. These NKR(+) RORγt(+) cells are also potent producers of IL-22 but it is unclear whether they are part of the NK cell or LTi cell lineage. This review will highlight recent progress in understanding development and function of innate IL-22-producing lymphocyte subsets.
摘要
现在越来越明显的是，先天淋巴细胞的防御系统比以前认识到的更加多样化。除了自然杀伤 (NK) 细胞、淋巴组织诱导 (LTi) 细胞和自然辅助细胞外，现在已经确定了这些细胞。LTi 细胞在发育上依赖于孤儿转录因子 RORγt，并在胚胎发生过程中指导淋巴结发育。最近，人们已经意识到，除了在淋巴器官发育中的作用外，LTi 细胞在成年小鼠中也是细胞因子如白细胞介素-22 (IL-22) 和白细胞介素-17 (IL-17) 的有力产生者。除了 LTi 细胞外，另一个依赖于 RORγt 的先天淋巴细胞亚群也被鉴定出来，该亚群同时表达 RORγt 和 NK 细胞受体 (NKR)。这些 NKR(+) RORγt(+)细胞也是 IL-22 的有力产生者，但尚不清楚它们是否属于 NK 细胞或 LTi 细胞谱系。这篇综述将重点介绍在理解先天产生 IL-22 的淋巴细胞亚群的发育和功能方面的最新进展。
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