并发 2 型糖尿病的泛胰岛素过敏和严重脂肪萎缩。
Pan-insulin allergy and severe lipoatrophy complicating Type 2 diabetes.
机构信息
Department of Diabetes and Endocrinology, The Hillingdon Hospital, Uxbridge, UK.
出版信息
Diabet Med. 2011 Apr;28(4):500-3. doi: 10.1111/j.1464-5491.2010.03196.x.
BACKGROUND
Insulin allergy is a rare complication of insulin use. Localized lipoatrophy is also known to occur following subcutaneous injections of insulin.
CASE REPORT
A 53-year-old non-obese female patient with Type 2 diabetes displayed local allergic-type symptoms to all available insulin preparations. This was complicated by the development of severe lipoatrophy on her abdominal and thigh injection sites and subsequently resulted in suboptimal glycaemic control.
CONCLUSIONS
Whilst uncommon, insulin allergy and lipoatrophy can cause major problems in diabetic management. Potential pathophysiological mechanisms and a stepwise approach to management are discussed.
背景
胰岛素过敏是胰岛素使用的罕见并发症。皮下注射胰岛素后也会出现局部脂肪萎缩。
病例报告
一名 53 岁非肥胖的 2 型糖尿病女性患者对所有可用的胰岛素制剂均表现出局部过敏样症状。这种情况还伴有严重的腹部和大腿注射部位脂肪萎缩，随后导致血糖控制不佳。
结论
尽管罕见，但胰岛素过敏和脂肪萎缩会给糖尿病管理带来重大问题。讨论了潜在的病理生理学机制和逐步管理方法。
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