Hussein S F, Siddique H, Coates P, Green J
Stafford District Hospital--Diabetes and Endocrine, Stafford, Staffordshire, UK.
Diabet Med. 2007 Dec;24(12):1470-2. doi: 10.1111/j.1464-5491.2007.02300.x. Epub 2007 Nov 1.
We describe the development of severe lipoatrophy in a patient treated with biphasic aspart. This complication of insulin therapy was common in the past with the use of animal insulins and became less common with the increasing purification of these and the introduction of recombinant human insulin. This patient developed severe lipoatrophy with the use of a premixed insulin containing the analogue insulin aspart. Lipoatrophy although rare can still occur even with the use of technologically advanced insulin preparations.
我们描述了一名使用双相门冬胰岛素治疗的患者发生严重脂肪萎缩的情况。胰岛素治疗的这种并发症在过去使用动物胰岛素时很常见，随着胰岛素纯度的提高以及重组人胰岛素的引入，这种情况变得不那么常见了。该患者在使用含门冬胰岛素类似物的预混胰岛素时出现了严重脂肪萎缩。即使使用技术先进的胰岛素制剂，脂肪萎缩虽然罕见但仍可能发生。
