Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA.
Alzheimers Res Ther. 2011 Feb 28;3(1):6. doi: 10.1186/alzrt65.
There are more than 36 million people in the US over the age of 65, and all of them are impacted by the cognitive decline and brain atrophy associated with normal aging and dementia-causing conditions like Alzheimer's disease, Lewy body disease, and vascular dementia. Recently, moderate exercise and improved fitness have been shown to enhance cognition in cognitively normal older persons as well as in individuals who complain of memory difficulty. Additionally, fitness correlates with brain volume in persons who are cognitively normal and those with Alzheimer's disease. Exercise in mouse models causes neurogenesis in the dentate gyrus. This review will discuss animal experiments, epidemiology, limited prospective studies, and biomarker data that make the case that prospective blinded studies are urgently needed to evaluate the role of aerobic exercise in protecting against dementia.
美国有超过 3600 万人年龄在 65 岁以上，所有人都受到与正常衰老以及阿尔茨海默病、路易体病和血管性痴呆等导致痴呆的疾病相关的认知能力下降和脑萎缩的影响。最近，适度运动和提高健康水平已被证明可以提高认知正常的老年人以及有记忆障碍的个体的认知能力。此外，健康水平与认知正常者和阿尔茨海默病患者的大脑体积相关。在老鼠模型中的运动导致齿状回的神经发生。本综述将讨论动物实验、流行病学、有限的前瞻性研究和生物标志物数据，这些数据表明迫切需要进行前瞻性、盲法研究来评估有氧运动在预防痴呆中的作用。
