纳格里亚虫基因组：自由生活的微生物真核生物为核心真核细胞生物学提供了独特的见解。
The Naegleria genome: a free-living microbial eukaryote lends unique insights into core eukaryotic cell biology.
机构信息
Department of Cellular and Molecular Pharmacology, UCSF Medical School, San Francisco, CA 94107, USA.
出版信息
Res Microbiol. 2011 Jul-Aug;162(6):607-18. doi: 10.1016/j.resmic.2011.03.003. Epub 2011 Mar 21.
Abstract
Naegleria gruberi, a free-living protist, has long been treasured as a model for basal body and flagellar assembly due to its ability to differentiate from crawling amoebae into swimming flagellates. The full genome sequence of Naegleria gruberi has recently been used to estimate gene families ancestral to all eukaryotes and to identify novel aspects of Naegleria biology, including likely facultative anaerobic metabolism, extensive signaling cascades, and evidence for sexuality. Distinctive features of the Naegleria genome and nuclear biology provide unique perspectives for comparative cell biology, including cell division, RNA processing and nucleolar assembly. We highlight here exciting new and novel aspects of Naegleria biology identified through genomic analysis.
摘要
纳格里虫，一种自由生活的原生动物，由于其能够从爬行变形虫分化为游动鞭毛虫，因此长期以来一直被视为基体和鞭毛组装的模型。纳格里虫的全基因组序列最近被用于估计所有真核生物的祖先进化基因家族，并鉴定纳格里虫生物学的新方面，包括可能的兼性厌氧代谢、广泛的信号级联以及有性生殖的证据。纳格里虫基因组和核生物学的独特特征为比较细胞生物学提供了独特的视角，包括细胞分裂、RNA 处理和核仁组装。我们在这里重点介绍通过基因组分析鉴定的纳格里虫生物学的令人兴奋的新方面和新方面。
相似文献
1
The Naegleria genome: a free-living microbial eukaryote lends unique insights into core eukaryotic cell biology.纳格里亚虫基因组：自由生活的微生物真核生物为核心真核细胞生物学提供了独特的见解。
Res Microbiol. 2011 Jul-Aug;162(6):607-18. doi: 10.1016/j.resmic.2011.03.003. Epub 2011 Mar 21.
2
The genome of Naegleria gruberi illuminates early eukaryotic versatility.格氏嗜热四膜虫基因组揭示了早期真核生物的多功能性。
Cell. 2010 Mar 5;140(5):631-42. doi: 10.1016/j.cell.2010.01.032.
3
Ancestral centriole and flagella proteins identified by analysis of Naegleria differentiation.通过分析纳氏疟原虫的分化，鉴定出中心粒和鞭毛的祖先蛋白。
J Cell Sci. 2010 Dec 1;123(Pt 23):4024-31. doi: 10.1242/jcs.077453. Epub 2010 Nov 2.
4
A calcineurin-B-encoding gene expressed during differentiation of the amoeboflagellate Naegleria gruberi contains two introns.在变形鞭毛虫纳氏虫分化过程中表达的一种编码钙调神经磷酸酶B的基因含有两个内含子。
Gene. 1995 Feb 27;154(1):39-45. doi: 10.1016/0378-1119(94)00860-u.
5
A nonmitochondrial hydrogen production in Naegleria gruberi.格氏梨形虫中的非线粒体产氢
Genome Biol Evol. 2014 Apr;6(4):792-9. doi: 10.1093/gbe/evu065.
6
A flagellar calmodulin gene of Naegleria, coexpressed during differentiation with flagellar tubulin genes, shares DNA, RNA, and encoded protein sequence elements.耐格里属的一个鞭毛钙调蛋白基因，在分化过程中与鞭毛微管蛋白基因共同表达，共享DNA、RNA和编码蛋白序列元件。
J Biol Chem. 1995 Mar 17;270(11):5839-48. doi: 10.1074/jbc.270.11.5839.
7
Lipids Are the Preferred Substrate of the Protist Naegleria gruberi, Relative of a Human Brain Pathogen.脂质是原生动物纳氏克虫的首选底物，纳氏克虫是一种人类脑部病原体的相关生物。
Cell Rep. 2018 Oct 16;25(3):537-543.e3. doi: 10.1016/j.celrep.2018.09.055.
8
Plant-type mitochondrial RNA editing in the protist Naegleria gruberi.原生动物 Naegleria gruberi 中的植物型线粒体 RNA 编辑。
RNA. 2011 Dec;17(12):2058-62. doi: 10.1261/rna.02962911. Epub 2011 Oct 24.
9
Naegleria's mitotic spindles are built from unique tubulins and highlight core spindle features.纳氏虫的有丝分裂纺锤体由独特的微管蛋白构成，突出了核心纺锤体特征。
Curr Biol. 2022 Mar 28;32(6):1247-1261.e6. doi: 10.1016/j.cub.2022.01.034. Epub 2022 Feb 8.
10
Transcriptional regulation of coordinate changes in flagellar mRNAs during differentiation of Naegleria gruberi amebae into flagellates.在格氏耐格里变形虫分化为鞭毛虫的过程中，鞭毛mRNA协同变化的转录调控。
Mol Cell Biol. 1988 Jun;8(6):2280-7. doi: 10.1128/mcb.8.6.2280-2287.1988.
引用本文的文献
1
Exploring the extrachromosomal plasmid rDNA of Naegleria fowleri AY27 genotype II: A human brain-eating amoeba via high-throughput sequencing.探索福氏耐格里阿米巴 AY27 基因型 II 的染色体外质粒 rDNA：一种通过高通量测序的食人脑阿米巴。
BMC Med Genomics. 2024 May 7;17(1):125. doi: 10.1186/s12920-024-01890-y.
2
Seriously cilia: A tiny organelle illuminates evolution, disease, and intercellular communication.严肃的纤毛：一个微小的细胞器照亮了进化、疾病和细胞间通讯。
Dev Cell. 2023 Aug 7;58(15):1333-1349. doi: 10.1016/j.devcel.2023.06.013. Epub 2023 Jul 24.
3
Bacterial Type II Secretion System and Its Mitochondrial Counterpart.细菌 II 型分泌系统及其线粒体对应物。
mBio. 2023 Apr 25;14(2):e0314522. doi: 10.1128/mbio.03145-22. Epub 2023 Mar 27.
4
Extensive Cryptic Diversity and Ecological Associations Uncovered among Mexican and Global Collections of and Species by 18S Ribosomal DNA, Internal Transcribed Spacer, and Cytochrome Oxidase Subunit I Sequence Analysis.通过18S核糖体DNA、内部转录间隔区和细胞色素氧化酶亚基I序列分析在墨西哥及全球范围内的[物种名称]和[物种名称]样本中发现广泛的隐秘多样性和生态关联
Microbiol Spectr. 2023 Mar 21;11(2):e0379522. doi: 10.1128/spectrum.03795-22.
5
genus pangenome reveals new structural and functional insights into the versatility of these free-living amoebae.泛基因组揭示了这些自由生活变形虫多功能性的新结构和功能见解。
Front Microbiol. 2023 Feb 1;13:1056418. doi: 10.3389/fmicb.2022.1056418. eCollection 2022.
6
Copper Metabolism in and Its Deadly Relative .体内的铜代谢及其致命相关因素。
Front Cell Dev Biol. 2022 Apr 11;10:853463. doi: 10.3389/fcell.2022.853463. eCollection 2022.
7
Localization and functional characterization of the alternative oxidase in Naegleria.在纳氏疟原虫中替代氧化酶的定位和功能特征。
J Eukaryot Microbiol. 2022 Jul;69(4):e12908. doi: 10.1111/jeu.12908. Epub 2022 May 3.
8
Naegleria's mitotic spindles are built from unique tubulins and highlight core spindle features.纳氏虫的有丝分裂纺锤体由独特的微管蛋白构成，突出了核心纺锤体特征。
Curr Biol. 2022 Mar 28;32(6):1247-1261.e6. doi: 10.1016/j.cub.2022.01.034. Epub 2022 Feb 8.
9
Evolution of glutamatergic signaling and synapses.谷氨酸能信号传递和突触的演变。
Neuropharmacology. 2021 Nov 1;199:108740. doi: 10.1016/j.neuropharm.2021.108740. Epub 2021 Jul 31.
10
Evolutionary History of Mitochondrial Genomes in Discoba, Including the Extreme Halophile Pleurostomum flabellatum (Heterolobosea).盘藻目线粒体基因组的进化历史，包括极端嗜盐菌扇状盘藻（异变形目）。
Genome Biol Evol. 2021 Feb 3;13(2). doi: 10.1093/gbe/evaa241.
本文引用的文献
1
Genetic structure of natural populations of the free-living amoeba, Naegleria lovaniensis. Evidence for sexual reproduction.自由生活变形虫洛万内格里亚自然种群的遗传结构。有性生殖的证据。
Heredity (Edinb). 1992 Feb;68(2):173-181. doi: 10.1038/hdy.1992.26.
2
Sawyeria marylandensis (Heterolobosea) has a hydrogenosome with novel metabolic properties.马里兰锯叶藻（异叶藻纲）具有一种具有新颖代谢特性的氢化酶体。
Eukaryot Cell. 2010 Dec;9(12):1913-24. doi: 10.1128/EC.00122-10. Epub 2010 Oct 29.
3
Intermediary metabolism in protists: a sequence-based view of facultative anaerobic metabolism in evolutionarily diverse eukaryotes.原生生物的中间代谢：基于序列的真核生物进化多样性兼性厌氧代谢观。
Protist. 2010 Dec;161(5):642-71. doi: 10.1016/j.protis.2010.09.001. Epub 2010 Oct 30.
4
Systematically fragmented genes in a multipartite mitochondrial genome.系统碎片化基因在一个多部分线粒体基因组中。
Nucleic Acids Res. 2011 Feb;39(3):979-88. doi: 10.1093/nar/gkq883. Epub 2010 Oct 8.
5
DYW-type PPR proteins in a heterolobosean protist: plant RNA editing factors involved in an ancient horizontal gene transfer?一种异变形体原生生物中的 DYW 型 PPR 蛋白：参与古老水平基因转移的植物 RNA 编辑因子？
FEBS Lett. 2010 Oct 22;584(20):4287-91. doi: 10.1016/j.febslet.2010.09.041. Epub 2010 Oct 2.
6
The genome of Naegleria gruberi illuminates early eukaryotic versatility.格氏嗜热四膜虫基因组揭示了早期真核生物的多功能性。
Cell. 2010 Mar 5;140(5):631-42. doi: 10.1016/j.cell.2010.01.032.
7
Evolution of macromolecular import pathways in mitochondria, hydrogenosomes and mitosomes.线粒体、氢化体和线粒体中大分子导入途径的进化。
Philos Trans R Soc Lond B Biol Sci. 2010 Mar 12;365(1541):799-817. doi: 10.1098/rstb.2009.0167.
8
Organization and expression of organellar genomes.细胞器基因组的组织和表达。
Philos Trans R Soc Lond B Biol Sci. 2010 Mar 12;365(1541):785-97. doi: 10.1098/rstb.2009.0250.
9
The hydrogenosomes of Psalteriomonas lanterna.灯眼虫属的氢化体。
BMC Evol Biol. 2009 Dec 9;9:287. doi: 10.1186/1471-2148-9-287.
10
Cascades of convergent evolution: the corresponding evolutionary histories of euglenozoans and dinoflagellates.趋同进化的级联：眼虫类和甲藻的相应进化史。
Proc Natl Acad Sci U S A. 2009 Jun 16;106 Suppl 1(Suppl 1):9963-70. doi: 10.1073/pnas.0901004106. Epub 2009 Jun 15.
Zotero 插件