Department of Pediatrics, Boston University School of Medicine, Boston, MA 02118, USA.
J Pediatr. 2011 Jul;159(1):14-20.e1. doi: 10.1016/j.jpeds.2011.01.049. Epub 2011 Mar 10.
To examine whether the relationship between obesity and asthma in young girls and boys can be explained by social and physical characteristics of the home environment.
We examined the relationship between asthma and obesity in children in the Fragile Families and Child Wellbeing Study (n=1815). Asthma was determined through maternal report of asthma diagnosis by a doctor (active in past 12 months). Weight and height of child was measured during an in-home visit. Data on home social (maternal depression, intimate partner violence) and physical environmental factors (housing quality, tobacco exposure) were collected via questionnaire.
Ten percent of children had active asthma, 19% of children were overweight, and 17% of children were obese. In fully adjusted models, obese children had twice the odds of having asthma (OR, 2.3; 95% CI, 1.5-3.3) compared with children of normal body weight. In stratified analyses, overweight boys, but not overweight girls, had increased of odds of asthma. Obese boys and girls had increased odds of asthma compared with boys and girls of normal body weight.
The relationship between asthma and obesity is present in boys and girls as young as 3 years of age; a relationship between being overweight and asthma is only present among boys. This relationship is not attributable to shared social and environmental factors of the children's home.
探讨家庭环境的社会和物理特征是否可以解释肥胖与青少年哮喘之间的关系。
我们在脆弱家庭和儿童福利研究（n=1815）中检查了儿童哮喘与肥胖之间的关系。哮喘通过母亲报告医生诊断（过去 12 个月内活跃）来确定。在家庭访问期间测量儿童的体重和身高。通过问卷收集有关家庭社会（母亲抑郁、亲密伴侣暴力）和物理环境因素（住房质量、烟草暴露）的数据。
10%的儿童患有活动性哮喘，19%的儿童超重，17%的儿童肥胖。在完全调整的模型中，肥胖儿童患哮喘的几率是正常体重儿童的两倍（OR，2.3；95%CI，1.5-3.3）。在分层分析中，超重男孩而不是超重女孩患哮喘的几率增加。与正常体重的男孩和女孩相比，肥胖的男孩和女孩患哮喘的几率增加。
哮喘和肥胖之间的关系在 3 岁的男孩和女孩中就存在；超重与哮喘之间的关系仅存在于男孩中。这种关系不是由于儿童家庭的共同社会和环境因素造成的。
