利用选择性微粒体Ca2+ -ATP酶抑制剂毒胡萝卜素研究Ca2+ -ATP酶在细胞Ca2+ 信号调节中的作用。 - Suppr | 超能文献

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Role of Ca2(+)-ATPases in regulation of cellular Ca2+ signalling, as studied with the selective microsomal Ca2(+)-ATPase inhibitor, thapsigargin.利用选择性微粒体Ca2+ -ATP酶抑制剂毒胡萝卜素研究Ca2+ -ATP酶在细胞Ca2+ 信号调节中的作用。

Agents Actions. 1990 Jan;29(1-2):8-15. doi: 10.1007/BF01964706.

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Calcium oscillations in parotid acinar cells induced by microsomal Ca(2+)-ATPase inhibition.微粒体钙（2+）-ATP酶抑制诱导腮腺腺泡细胞钙振荡

Am J Physiol. 1992 Mar;262(3 Pt 1):C656-63. doi: 10.1152/ajpcell.1992.262.3.C656.

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Direct involvement of intracellular Ca2+ transport ATPase in the development of thapsigargin resistance by Chinese hamster lung fibroblasts.中国仓鼠肺成纤维细胞中细胞内钙离子转运ATP酶直接参与毒胡萝卜素抗性的形成。

J Biol Chem. 1995 May 19;270(20):12140-6. doi: 10.1074/jbc.270.20.12140.

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Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.毒胡萝卜素是一种肿瘤促进剂，它通过特异性抑制内质网Ca2(+)-ATP酶来释放细胞内的Ca2+储备。

Proc Natl Acad Sci U S A. 1990 Apr;87(7):2466-70. doi: 10.1073/pnas.87.7.2466.

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Basal Mg(2+)-dependent ATPase activity of rat liver microsomes is not influenced by ambient free Ca2+.大鼠肝脏微粒体的基础镁离子依赖性ATP酶活性不受细胞外游离钙离子的影响。

Eur J Biochem. 1993 Dec 15;218(3):959-62. doi: 10.1111/j.1432-1033.1993.tb18453.x.

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Thapsigargin-sensitive Ca(2+)-ATPases account for Ca2+ uptake to inositol 1,4,5-trisphosphate-sensitive and caffeine-sensitive Ca2+ stores in adrenal chromaffin cells.毒胡萝卜素敏感的Ca(2+) -ATP酶负责将Ca2+摄取到肾上腺嗜铬细胞中对肌醇1,4,5 -三磷酸敏感和对咖啡因敏感的Ca2+储存库中。

Biochem J. 1995 May 1;307 ( Pt 3)(Pt 3):749-58. doi: 10.1042/bj3070749.

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Brain microsomal calcium accumulation in rats with increasing age: involvement of thapsigargin-sensitive Ca2+-ATPase.随着年龄增长大鼠脑微粒体钙蓄积：毒胡萝卜素敏感的Ca2 + -ATP酶的作用

Int J Mol Med. 1999 Dec;4(6):627-31. doi: 10.3892/ijmm.4.6.627.

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Comparison between the effects of the microsomal Ca(2+)-translocase inhibitors thapsigargin and 2,5-di-(t-butyl)-1,4-benzohydroquinone on cellular calcium fluxes.微粒体钙转运酶抑制剂毒胡萝卜素和2,5-二（叔丁基）-1,4-苯二酚对细胞钙通量影响的比较。

Biochem J. 1991 Jul 15;277 ( Pt 2)(Pt 2):553-6. doi: 10.1042/bj2770553.

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Isolation of chromaffin cell thapsigargin-sensitive Ca2+ store in light microsomes from bovine adrenal medulla.从牛肾上腺髓质的轻微粒体中分离嗜铬细胞毒胡萝卜素敏感的Ca2+储存库。

Int J Biochem. 1993 May;25(5):641-52. doi: 10.1016/0020-711x(93)90348-i.

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Thapsigargin discriminates strongly between Ca(2+)-ATPase phosphorylated intermediates with different subcellular distributions in bovine adrenal chromaffin cells.

FEBS Lett. 1995 Dec 11;377(1):31-6. doi: 10.1016/0014-5793(95)01304-0.

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ER calcium stores contribute to glucose-induced Ca waves and intercellular connectivity in mouse pancreatic islets.内质网钙库有助于小鼠胰岛中葡萄糖诱导的钙波和细胞间连接。

bioRxiv. 2025 Mar 14:2025.03.14.643121. doi: 10.1101/2025.03.14.643121.

2

Age-related changes in P2Y receptor signalling in mouse cochlear supporting cells.小鼠耳蜗支持细胞中 P2Y 受体信号转导的年龄相关性变化。

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The UPR sensor IRE1α and the adenovirus E3-19K glycoprotein sustain persistent and lytic infections.

本文引用的文献

1

Vasopressin-, angiotensin II-, and alpha 1-adrenergic-induced inhibition of Ca2+ transport by rat liver plasma membrane vesicles.血管加压素、血管紧张素II和α1-肾上腺素能诱导大鼠肝细胞膜囊泡对Ca2+转运的抑制作用。

J Biol Chem. 1984 Feb 10;259(3):1382-5.

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Acidic phospholipids, unsaturated fatty acids, and limited proteolysis mimic the effect of calmodulin on the purified erythrocyte Ca2+ - ATPase.酸性磷脂、不饱和脂肪酸和有限的蛋白水解作用模拟了钙调蛋白对纯化的红细胞钙ATP酶的作用。

J Biol Chem. 1981 Aug 25;256(16):8588-92.

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The Ca2+-pumping ATPase of heart sarcolemma. Characterization, calmodulin dependence, and partial purification.