5-HT 与免疫系统。
5-HT and the immune system.
机构信息
Department of Pharmacology, Georgetown University, 3900 Reservoir Rd NW, Washington, DC 20007, United States.
出版信息
Curr Opin Pharmacol. 2011 Feb;11(1):29-33. doi: 10.1016/j.coph.2011.02.004. Epub 2011 Mar 8.
Abstract
The classical neurotransmitter, serotonin (5-HT), plays an important role outside of the central nervous system in immune signaling. Here I review recent studies describing 5-HT uptake in dendritic cells and B lymphocytes, 5-HT synthesis in T lymphocytes, and the role of specific 5-HT receptor subtypes in innate and adaptive immune cells. Furthermore, a recent paper describing the immune phenotype of 5-HT deficient mice is discussed.
摘要
经典神经递质 5-羟色胺（5-HT）在中枢神经系统外的免疫信号中发挥着重要作用。在这里，我回顾了最近描述树突状细胞和 B 淋巴细胞中 5-HT 摄取、T 淋巴细胞中 5-HT 合成以及特定 5-HT 受体亚型在固有和适应性免疫细胞中的作用的研究。此外，还讨论了最近一篇描述 5-HT 缺乏小鼠免疫表型的论文。
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