University of Belfrade, Mothers and Child Health Care Institute, Dr. Vukan Cupic, Belgrade, Serbia.
Epileptic Disord. 2011 Mar;13(1):22-6. doi: 10.1684/epd.2011.0402.
The syndrome of malignant migrating partial seizures in infancy is a devastating, age-specific, epileptic encephalopathy, which still presents an aetiological, pathophysiological and therapeutic problem. In this study, we present two patients who were diagnosed with the disease, based on electroclinical symptoms. The patients were treated with a combination of sodium bromide, stiripentol and levetiracetam. The first patient unequivocally responded, following a course of ineffective conventional drugs, and the second, who was diagnosed and treated immediately, showed a more significant therapeutic response. Antiepileptic drugs, previously reported to be beneficial in case reports, when given concomitantly, may substantially reduce the number and severity of seizures, without influence on psychomotor development. [Published with video sequences].
婴儿恶性游走性部分性癫痫综合征是一种具有破坏性的、特定于年龄的癫痫性脑病，目前仍然存在病因、病理生理和治疗方面的问题。在这项研究中，我们根据电临床症状，介绍了两名被诊断为该病的患者。这两名患者接受了溴化钠、司替戊醇和左乙拉西坦联合治疗。第一位患者在经历了一系列常规药物治疗无效后，对治疗有明确的反应，第二位患者在被明确诊断和立即治疗后，显示出了更显著的治疗反应。在病例报告中曾有报道称，一些抗癫痫药物联合使用时，可能会显著减少发作的次数和严重程度，而对精神运动发育没有影响。[附有视频序列]。
