Hmaimess Ghassan, Kadhim Hazim, Nassogne Marie-Cécile, Bonnier Christine, van Rijckevorsel Kenou
Neurologie Pédiatrique, Cliniques Universitaires Saint Luc (UCL), Brussels, Belgium.
Pediatr Neurol. 2006 Jan;34(1):55-9. doi: 10.1016/j.pediatrneurol.2005.06.011.
This report describes the first neonatal case of "malignant migrating partial seizures in infancy" with a positive therapeutic response to levetiracetam. This patient is the youngest reported infant with this rare syndrome, and the report provides the first documentation on levetiracetam treatment in a neonatal patient. Treatment with levetiracetam improved both ictal and interictal status. This observation also highlights the need to consider and include malignant migrating partial seizures in the differential diagnosis of early neonatal seizure disorders, even during the first hours of life.
本报告描述了首例对左乙拉西坦治疗有积极反应的“婴儿期恶性游走性部分性癫痫”新生儿病例。该患者是报道的患有这种罕见综合征的最年幼婴儿，本报告首次记录了左乙拉西坦在新生儿患者中的治疗情况。左乙拉西坦治疗改善了发作期和发作间期状态。这一观察结果还强调，即使在生命的最初几个小时，在早期新生儿癫痫障碍的鉴别诊断中也需要考虑并纳入恶性游走性部分性癫痫。
