具有抗分枝杆菌活性的新型 S-苄基异硫代氰酸脒。

New S-benzylisothiosemicarbazones with antimycobacterial activity.

机构信息

Department of Inorganic and Organic Chemistry, Faculty of Pharmacy in Hradec Králové, Charles University in Prague, 500 05, Hradec Králové, Czech Republic.

出版信息

Folia Microbiol (Praha). 2011 Jan;56(1):10-2. doi: 10.1007/s12223-011-0015-3. Epub 2011 Mar 11.

DOI:10.1007/s12223-011-0015-3

PMID:21394476

Abstract

Benzaldehyde- and salicylaldehyde-S-benzylisothiosemicarbazones show a moderate to high in vitro activity against Mycobacterium tuberculosis, Mycobacterium avium and two strains of Mycobacterium kansasii. Benzaldehyde-S-4-bromobenzylisothiosemicarbazone and salicylaldehyde-S-4-chlorobenzylisothiosemicarbazone have the most promising antimycobacterial properties.

摘要

苯甲醛-和水杨醛-S-苄基异硫代氰酸脒显示出对结核分枝杆菌、鸟分枝杆菌和两种堪萨斯分枝杆菌菌株具有中等至高的体外活性。苯甲醛-S-4-溴苄基异硫代氰酸脒和水杨醛-S-4-氯苄基异硫代氰酸脒具有最有前途的抗分枝杆菌特性。