新型抗分枝杆菌S-烷基异硫脲腙类化合物。
New antimycobacterial S-alkylisothiosemicarbazones.
作者信息
Waisser K, Heinisch L, Slosárek M, Janota J
机构信息
Department of Inorganic and Organic Chemistry, Charles University, Faculty of Pharmacy, Hradec Králové, Czechia.
出版信息
Folia Microbiol (Praha). 2005;50(6):479-81. doi: 10.1007/BF02931433.
In connection with a systematic study of antimycobacterial agents against potentially pathogenic strains the series of 12 S-alkylisothiosemicarbazones was evaluated for in vitro antimycobacterial activity against Mycobacterium tuberculosis, M. kansasii, M. fortuitum, two strains of M. intracellulare and three strains of M. avium. Quinoline-4-carbaldehyde-S-hexyl-isothiohydrazone was found to be more active against potentially pathogenic strains than isoniazide.
在针对潜在致病菌株的抗分枝杆菌药物的系统研究中，对一系列12种S-烷基异硫脲腙进行了评估，以考察其对结核分枝杆菌、堪萨斯分枝杆菌、偶然分枝杆菌、两株胞内分枝杆菌和三株鸟分枝杆菌的体外抗分枝杆菌活性。发现喹啉-4-甲醛-S-己基异硫腙对潜在致病菌株的活性比异烟肼更强。
Zotero 插件