Department of Anesthesiology, Université Catholique de Louvain, Cliniques Universitaires Saint Luc, Avenue Hippocrate 10/1821, 1200, Brussels, Belgium.
Eur J Appl Physiol. 2011 Nov;111(11):2681-6. doi: 10.1007/s00421-011-1893-4. Epub 2011 Mar 11.
Previous studies in healthy subjects have shown an increase in erythropoietin (EPO) production after administration of N-acetyl-cysteine (NAC). These authors hypothesized that NAC increases intracellular reduced glutathione, decreasing reactive oxygen species and enabling EPO production. We investigated if EPO production could be stimulated with a single dose of NAC, after 90 min of pure oxygen breathing. Thirty-eight healthy volunteers were randomized into either the control (C) group or the NAC group, which received 600 mg NAC PO dissolved in a glass of orange juice, 60 min before breathing 15 L/min of 100% normobaric oxygen. Orange juice was administered to both groups. Blood samples for EPO measurement were taken at T0, before the orange juice administration, and T1, T2, T3 and T4, respectively, 8, 24, 32 and 48 h after the orange juice. The EPO concentrations of the NAC group decreased significantly at T1, followed by a significant increase compared to baseline, which was obvious until T4. The EPO concentrations of the C group did not show any significant variations. In this study, a significant increase of EPO production was observed after a short-term hyperoxic stimulus only when preceded with the administration of a single dose of NAC.
先前在健康受试者中的研究表明，给予 N-乙酰半胱氨酸（NAC）后会增加促红细胞生成素（EPO）的产生。这些作者假设 NAC 会增加细胞内还原型谷胱甘肽的含量，减少活性氧物质的产生，从而促进 EPO 的产生。我们研究了在单次给予 NAC 后，经过 90 分钟纯氧呼吸是否可以刺激 EPO 的产生。38 名健康志愿者被随机分为对照组（C 组）或 NAC 组，NAC 组在吸入 15L/min、100%常压纯氧前 60 分钟口服 600mg NAC PO 溶解在一杯橙汁中。两组均给予橙汁。在 T0（服用橙汁前）和 T1、T2、T3 和 T4（分别为橙汁服用后 8、24、32 和 48 小时）采集血样以测量 EPO。NAC 组的 EPO 浓度在 T1 时显著降低，随后与基线相比显著升高，直至 T4 时仍很明显。C 组的 EPO 浓度没有显示出任何显著变化。在这项研究中，仅在短期高氧刺激前给予单次剂量 NAC 时，才观察到 EPO 产生的显著增加。
