Iskesen I, Eserdag M, Kurdal A T, Cerrahoglu M, Sirin B H
Department of Cardiovascular Surgery, Celal Bayar Univ, Manisa, Turkey.
Thorac Cardiovasc Surg. 2011 Jun;59(4):213-6. doi: 10.1055/s-0030-1250356. Epub 2011 Mar 10.
Atrial fibrillation (AF) is one of the most common complications after coronary artery bypass grafting (CABG). This study was designed to evaluate whether the levels of preoperative and postoperative N-terminal pro-brain natriuretic peptide (NT-proBNP) are predictors of postoperative paroxysmal atrial fibrillation in patients who undergo coronary artery bypass surgery.
A total of 117 patients were prospectively evaluated for new-onset AF after coronary operation. Plasma NT-proBNP values in all patients were measured at five different time points.
AF occurred during the hospitalization period in 33 patients (28.2 %). Significantly higher NT-proBNP levels in the preoperative examination were recorded in patients who developed AF postoperatively compared with patients without postoperative AF (329.36 ± 82.93 vs. 230.67 ± 59.93 pg/ml, P < 0.05). Although we detected some higher values in the other group of patients with AF (at T1, T2, T3, T4), the difference was not statistically significant compared to the normal rhythm group.
The main finding of the current study is a positive correlation between high levels of preoperative NT-proBNP and the risk of new-onset AF after CABG surgery.
心房颤动（AF）是冠状动脉旁路移植术（CABG）后最常见的并发症之一。本研究旨在评估冠状动脉搭桥手术患者术前和术后N端前脑钠肽（NT-proBNP）水平是否为术后阵发性心房颤动的预测指标。
前瞻性评估117例冠状动脉手术后新发房颤患者。在五个不同时间点测量所有患者的血浆NT-proBNP值。
33例患者（28.2%）在住院期间发生房颤。术后发生房颤的患者术前检查中NT-proBNP水平显著高于未发生术后房颤的患者（329.36±82.93 vs. 230.67±59.93 pg/ml，P<0.05）。虽然我们在另一组房颤患者（在T1、T2、T3、T4）中检测到一些较高的值，但与正常心律组相比，差异无统计学意义。
本研究的主要发现是术前NT-proBNP水平升高与CABG术后新发房颤风险之间存在正相关。
